Systematic review and meta-analysis of adverse pregnancy outcomes after uterine adenomyosis

Maryam Razavi, Arezoo Maleki-Hajiagha, Arezoo Maleki‐Hajiagha, Sepidarkish M, Mahdi Sepidarkish, Safoura Rouholamin, Rouholamin S, Almasi-Hashiani A, Amir Almasi-Hashiani, Amir Almasi‐Hashiani, Rezaeinejad M, Mahroo Rezaeinejad
International Journal of Gynecology & Obstetrics · 2019 · vol. 145(2) , pp. 149–157 · doi:10.1002/ijgo.12799 · PMID:30828808 · W2918503691
Systematic review / meta-analysis OA: closed CC0 ⤵ 40 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This meta-analysis of six studies found that women with adenomyosis have a higher likelihood of preterm birth, small for gestational age, and pre-eclampsia compared to women without adenomyosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: Studies on the impact of adenomyosis and its pregnancy complications have yielded conflicting results. OBJECTIVE: To determine the likelihood of adverse pregnancy outcomes among women with adenomyosis relative to women without adenomyosis. SEARCH STRATEGY: PubMed, Embase, Scopus, and Web of Science were searched for studies published up to June 15, 2018. SELECTION CRITERIA: Observational studies with medically confirmed pregnancy outcomes as endpoints. DATA COLLECTION AND ANALYSIS: Two researchers independently screened and selected relevant studies. Dichotomous data for all adverse pregnancy outcomes were expressed as an odds ratio (OR) with 95% confidence interval (CI), and combined in a meta-analysis by using a random-effects model. MAIN RESULTS: Six studies (322 cases and 9420 controls) were eligible for inclusion in the meta-analysis. Women with adenomyosis had an increased likelihood of preterm birth (OR, 3.05; 95% CI, 2.08-4.47; P˂0.001), small for gestational age (OR, 3.22; 95% CI, 1.71-6.08; P˂0.001), and pre-eclampsia (OR, 4.35; 95% CI, 1.07-17.72; P=0.042). CONCLUSION: Adenomyosis seems to have a detrimental impact on pregnancy outcomes, resulting in a higher likelihood of preterm birth, small for gestational age, and pre-eclampsia.

My notes (saved in your browser only)

Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Pre-Eclampsia Pregnancy Complications Pregnancy Complications Premature Birth Adenomyosis Adenomyosis Case-Control Studies Case-Control Studies Female Female Humans Humans Infant, Newborn Infant, Newborn Infant, Small for Gestational Age Infant, Small for Gestational Age Observational Studies as Topic Observational Studies as Topic Pre-Eclampsia

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (42)

Cited by (42)

Source provenance

europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:24:09.876621+00:00
License: CC0 · commercial use OK