High intensity focused ultrasound treatment of adenomyosis: The relationship between the features of magnetic resonance imaging on T2 weighted images and the therapeutic efficacy

Gong C, Chunmei Gong, Setzen R, Raymond Setzen, Zhongqiong Liu, Liu Z, Yunchang Liu, Liu Y, Xie B, Bin Xie, Aixingzi Aili, Aili A, Zhang L, Lian Zhang
European journal of radiology · 2017 · vol. 89 , pp. 117–122 · doi:10.1016/j.ejrad.2017.02.001 · PMID:28267526 · W2584861573
article OA: closed CC0 ⤵ 21 in-corpus citations
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This study investigates the correlation between magnetic resonance imaging features on T2 weighted images and the therapeutic efficacy of high-intensity focused ultrasound (HIFU) treatment for adenomyosis.

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Abstract

ObjectivesTo investigate the relationship between the features of magnetic resonance imaging (MRI) on T2 weighted images (T2WI) and the therapeutic efficacy of high intensity focused ultrasound (HIFU) on adenomyosis.Materials and methodsFrom January 2011 to November 2015, four hundred and twenty-eight patients with symptomatic adenomyosis were treated with HIFU. Based on the signal intensity and the number of hyperintense foci in the adenomyotic lesions on T2WI, the patients were classified into groups. The day after HIFU ablation patients underwent contrast-enhanced MRI and a comparison was made of non-perfused volume (NPV) ratio, energy efficiency factor (EEF), treatment time, sonication time, and adverse effects.ResultsNo significant difference in terms of HIFU treatment settings and results was observed between the group of patients with hypointense adenomyotic lesions and the group with isointense adenomyotic lesions (P>0.05). However, the sonication time and EEF were significantly higher in the group with multiple hyperintense foci compared to the group with few hyperintense foci. The NPV ratio achieved in the lesions with multiple hyperintenese foci was significantly lower than that in the lesions with few hyperintense foci (P<0.05). No significant difference was observed in the rate of adverse effects between the two groups.ConclusionsBased on our results, the response of the adenomyotic lesions to HIFU treatment is not related to the signal intensity of adenomyotic lesions on T2WI. However, the number of the high signal intensity foci in the adenomyotic lesions on T2WI can be considered as a predictive factor to help select patients for HIFU treatment.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis High-Intensity Focused Ultrasound Ablation Adenomyosis Adult Female High-Intensity Focused Ultrasound Ablation Humans Magnetic Resonance Imaging Magnetic Resonance Imaging Middle Aged Retrospective Studies Treatment Outcome Young Adult

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