{"paper_id":"dc3b82af-cc4c-4e00-8afb-c43e967cea8f","body_text":"Abstract\nObjective\nThe primary aim of the study was to analyze the endometrioma recurrence rate in patients who underwent laparoscopic excision followed by postoperative long-term regimen of oral contraceptives (OCs).\nMaterials and methods\n168 patients who underwent a conservative laparoscopic surgery for endometrioma, during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all women following surgery. Patients were randomly divided into three groups according to different progestins used (desogestrel, gestodene, dienogest). Women who refused a postoperative hormonal therapy served as control. Follow-up visits and transvaginal scan were planned at 1, 3, 6, 12, and 24 months after surgery. All patients who showed an ultrasound persistence of the endometrioma at 1 month follow-up were excluded from clinical analysis.\nResults\nOf the 168 patients, 131 completed the 24 months follow-up. Endometrioma recurrence was found in 21 (12.5 %) of all patients, it was unilateral in 17 cases while bilateral in 4 cases. The rate of recurrent endometrioma was statistically significant in non-users compared to the long-term OCs treated patients.\nConclusion\nThe current data suggest the usefulness of long-term OCs regimen after conservative surgery for the prevention of ovarian endometrioma recurrence. As a statistical significant difference could not be observed between OCs groups, further study on the individual molecules is required in order to really understand the effect of each of them.\nSimilar content being viewed by others\nReferences\nEskenazi B, Warner ML (1997) Epidemiology of endometriosis. 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Granese are equal first authors.\nRights and permissions\nAbout this article\nCite this article\nCucinella, G., Granese, R., Calagna, G. et al. Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?. Arch Gynecol Obstet 288, 821–827 (2013). https://doi.org/10.1007/s00404-013-2841-9\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-013-2841-9","source_license":"CC0","license_restricted":false}