Role of Estrogens in Inflammatory Response
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Endometriosis patients' peritoneal macrophages overexpress both estrogen receptors alpha and beta compared to controls, suggesting estrogens modulate immune responses via these receptors.
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Abstract
Estrogens are involved in the immune response, and macrophages express estrogen receptors (ER). Moreover, macrophages are the predominant cell type in the peritoneal fluid from endometriosis patients. On this basis, the aim of our study was to evaluate the expression of ER on peritoneal macrophages from endometriosis patients and to compare these results with what is already known about ER and macrophages in RA. After macrophage extraction from peritoneal fluids we performed the immunohistochemical localization of ERalpha and ERbeta and then the image analysis. We found that both ERs were significantly overexpressed in macrophages of women with endometriosis compared with controls. These results suggest that estrogens, through their functional receptors, might modulate the immune response at least on macrophages. Therefore, estrogens seem to play an important role in the immune response, independently from the pathology.
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Cited by (25)
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- Endocrine disruptor hexachlorobenzene induces cell migration and invasion, and enhances aromatase expression levels in human endometrial stromal cells 2022
- Effect of combined contraceptive pill on immune cell of ovarian endometriotic tissue 2021
- The roles and functions of macrophages in endometriosis 2021
- Uterine Adenomyosis: From Disease Pathogenesis to a New Medical Approach Using GnRH Antagonists 2021
- Pain 2021
- Unique Sensitivity of Uterine Tissue and the Immune System for Endometriotic Lesion Formation 2021
- Establishment of an immortalized stromal cell line derived from human Endometriotic lesion 2020
- Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk 2017
- Inflammation and nerve fiber interaction in endometriotic pain 2014
- Aromatase and endometriosis: estrogens play a role 2014
- Extrapelvic endometriosis: a rare entity or an under diagnosed condition? 2013
- Inducers of G-protein coupled estrogen receptor (GPER) in endometriosis: potential implications for macrophages and follicle maturation 2013
- Role of Estrogen Receptor Signaling Required for Endometriosis-Like Lesion Establishment in a Mouse Model 2012
- Estrogen receptors and human disease: an update 2012
- Role of Inflammation and Aromatase Expression in the Eutopic Endometrium and its Relationship with the Development of Endometriosis 2012
- Prostaglandin E <sub>2</sub> : the master of endometriosis? 2010
- Pharmacological Treatment of Endometriosis 2009
- Is aromatase expression in the endometrium the cause of endometriosis and related infertility? 2009
- ERB-041, a selective ERβ agonist, inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-κB activation 2009
- The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis 2008
- Endometriosis 2008
- Targeting Mast Cells in Endometriosis with Janus Kinase 3 Inhibitor, JANEX‐1 2007
- Differential flow cytometric detection of intracellular cytokines in peripheral and peritoneal mononuclear cells of women with endometriosis 2007
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- europepmc
- last seen: 2026-06-17T06:13:18.893374+00:00
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- pubmed
- last seen: 2026-05-13T22:15:12.369988+00:00
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