Neonatal Uterine Bleeding and Adolescent Endometriosis
Neonatal uterine bleeding, occurring in 3.3–61.3% of female neonates, is influenced by fetal hypoxia and features endometrial morphology that may predispose to endometriosis via retrograde shedding.
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This chapter reviews neonatal uterine bleeding occurring on postpartum days 3–7, drawing on incidence data from German, French, and Serbian literature and on an autopsy description of newborn endometrium. It reports that visible bleeding occurs in 3.3–5.3% of female neonates and occult bleeding detected via hemoglobin testing in 25.4–61.3%, with lower incidence in preterm infants than in postmaturity and higher incidence reported in preeclampsia, and it proposes that fetal hypoxia may influence bleeding. The authors note that newborn uterine morphology may favor retrograde dissemination of menstrual shedding and references hypotheses that endometrial stem/progenitor cells present in neonatal menstruation could be linked to early-onset endometriosis, while the evidence is largely drawn from secondary literature and historical autopsy findings. This paper is centrally about endometriosis — it links neonatal uterine bleeding and neonatal endometrial physiology to the early onset of endometriosis in adolescents.
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