Clinical significance of neonatal menstruation

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This paper investigated the phenomenon of neonatal menstruation and its clinical implications in newborns.

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Abstract

Past studies have clearly shown the existence of a spectrum of endometrial progesterone responses in neonatal endometrium, varying from proliferation to full decidualization with menstrual-like shedding. The bleedings represent, similar to what occurs in adult menstruation, a progesterone withdrawal bleeding. Today, the bleeding is completely neglected and considered an uneventful episode of no clinical significance. Yet clinical studies have linked the risk of bleeding to a series of events indicating fetal distress. The potential link between the progesterone response and major adolescent disorders requires to be investigated by prospective studies.

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MeSH descriptors

Endometrium Menstruation Uterine Hemorrhage Endometrium Female Humans Infant, Newborn Menstruation Prospective Studies Uterine Hemorrhage

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Cited by (19)

Source provenance

europepmc
last seen: 2026-08-13T06:15:24.848197+00:00
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License: CC0 · commercial use OK