A review: Exposure to bisphenol a analogues in non-human primates as a potential cause of endometriosis

Oreng’ P Apiyo, Atunga Nyachieo, Almas R Juma, Ivy Mutai, Peter G. Mwethera, Ezekiel Mecha, Charles O. A. Omwandho, Ludwig Kiesel, Martin Götte, Charles Muteshi, Jael Obiero
In: Journal of Endometriosis and Pelvic Pain Disorders · 2024 · vol. 16(1) , pp. 53–60 · doi:10.1177/22840265241231323 · W4392985124
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This review highlights that bisphenol A and its analogues are endocrine disruptors that may cause endometriosis, with non-human primate studies needed to further investigate this link.

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Abstract

Introduction: Bisphenol A is a synthetic compound widely used in the production of polycarbonate plastics and epoxy resins worldwide. As an environmental toxin, it has been reported in plastic equipment and utensils, water bottles and bottle tops, water supply pipes and epoxy resins that coat most of the metal food cans. It is a known endocrine-disrupting chemical and has been progressively replaced by its derivatives including bisphenol S, bisphenol F, bisphenol E, bisphenol AF, bisphenol B and tetramethyl bisphenol F. Bisphenol A and its analogues can bind to estrogen receptors and trigger multiple cellular responses at the organism level. Methods: A comprehensive literature review was done utilising electronic databases of PubMed, Google Scholar, Hinari, Connected papers and Science Direct from 1991 onwards. The articles were only included if they reported original relevant research and were limited to articles written in English. Results: Animal models, including non-human primates, have been used to study their effects on the endocrine system. Its endocrine disruption activity is reported to be the most studied effect in reproductive biology indicating that it may potentially cause endometriosis in females. Though non-human primates are closely related to humans, limited data exists on their associations between Bisphenol A exposure and its analogues and the pathophysiology of endometriosis. Conclusion: Given the current multifaceted knowledge/theory on endometriosis etiology, there is a strong necessity to conduct further biomedical research that utilises non-human primates to study the link between endocrine-disrupting chemicals and its effects on endometriosis.
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Data availability statement Authors Metrics and citations Metrics Journals metrics This article was published in Journal of Endometriosis and Pelvic Pain Disorders. View All Journal MetricsPublication usage* Total views and downloads: 460 *Publication usage tracking started in December 2016 Publications citing this one Receive email alerts when this publication is cited Web of Science: 1 view articles Opens in new tab Crossref: 1 - Pollution profiles and human health risk assessment of BPA analogues in seafood from a Chinese coastal city Figures and tables Figures & Media Tables View Options Access options If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below: loading institutional access options Alternatively, view purchase options below: Purchase 24 hour online access to view and download content. Access journal content via a DeepDyve subscription or find out more about this option.

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