Clinical Conundrum: A 33-Year-Old With Pain Post-Orgasm and a History of Endometriosis

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AI-generated summary by gemini-2.5-flash-lite, 2026-07-09

This case report describes a 33-year-old woman with endometriosis who experienced post-orgasm pain and bleeding, which resolved with the gonadotropin-releasing hormone antagonist elagolix.

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Abstract

A 33-year-old with a history of endometriosis presented with pain post-orgasm, accompanied by breakthrough bleeding, nausea, sweatiness, and exhaustion. History and examination suggested a gynaecologic component, likely related to the uterus itself. After several therapeutic trials, a clinical response was obtained with the use of a gonadotropin-releasing hormone antagonist, elagolix. The case is discussed with respect to dysorgasmia and post-orgasm illness syndrome. Post-orgasm pain in women has not been well studied, and it is recommended that such periorgasm phenomena be the topic of future research.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Hormone Antagonists Hydrocarbons, Fluorinated Orgasm Pelvic Pain Pyrimidines Adult Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Hormone Antagonists Hormone Antagonists Humans Hydrocarbons, Fluorinated Orgasm Pelvic Pain Pelvic Pain Pelvic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (8)

Cited by (3)

SciLite annotations

chemicals 1
elagolix
organisms 1
noordeloos 2009062

Source provenance

europepmc
last seen: 2026-09-10T06:15:44.054944+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:21:59.141895+00:00
scilite
last seen: 2026-05-18T04:26:01.642840+00:00
License: CC0 · commercial use OK