Reinnervation of rat endometrium in the anterior eye chamber model of experimental endometriosis: Old methods for new questions

Patrícia Pelufo Silveira, Patricia Silveira, Silveira P, Texidor-Frugoni C, Camila Texidor-Frugoni, Martínez GF, Gaby F. Martínez, M. Mónica Brauer, Brauer MM
Autonomic neuroscience : basic & clinical · 2016 · vol. 201 , pp. 49–53 · doi:10.1016/j.autneu.2016.09.016 · PMID:27688077 · W2521296323
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This study investigated the reinnervation of rat endometrium within the anterior eye chamber model, utilizing established methods to address novel questions regarding endometriosis.

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Abstract

Endometriosis is a benign estrogen-dependent chronic gynecological disease characterized by the presence of endometrial-like tissue outside the uterine cavity. In both women and experimental endometriotic rats, endometriosis lesions endow autonomic and sensory nerves, which are thought to contribute to the disease-associated pain. Some evidence indicates that the reinnervation of lesions is regulated by factors produced by the endometrial tissue as well as by environmental factors from the peritoneum. In this study, we examined the reinnervation of the rat endometrial tissue in an ectopic environment different from the peritoneum employing the anterior eye chamber model of experimental endometriosis. At 3 and 6weeks following transplantation, endometrial grafts retained many histological features of the eutopic tissue. Both sympathetic and sensory nerves reinnervated endometrial grafts and distributed in the stroma-like tissue, around blood vessels and in close proximity to the glands and lining epithelium. Sympathetic innervation was more robust than sensory innervation. No significant topographical relationship between sympathetic nerves and macrophages was observed. These results suggest that the rat endometrium possesses intrinsic neuritogenic capacities and can be reinnervated by sympathetic and sensory nerves in ectopic sites different from the peritoneum.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Allografts Allografts Allografts Allografts Animals Calcitonin Gene-Related Peptide Calcitonin Gene-Related Peptide Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Immunohistochemistry Macrophages

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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