The morphological substrate and pathogenetic mechanisms of pelvic pain syndrome in endometriosis

Е А Коган, E A Kogan, Н. Б. Парамонова, N B Paramonova, Т. А. Демура, T A Demura, N M Faĭzullina, Н. М. Файзуллина, A S Ovakimian, Л В Адамян, L V Adamian
Arkhiv patologii · 2014 · vol. 76(6) , pp. 37 · doi:10.17116/patol201476637-43 · PMID:25842924 · W2227732199
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the morphological basis of pelvic pain in deep infiltrating endometriosis, finding that inflammation, fibrosis, and nerve fiber injury within endometriotic foci contribute to somatogenic and neuropathic pain.

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Abstract

OBJECTION: To study the origin and morphological substrate of pain syndrome in deep infiltrating endometriosis involving the bowel. SUBJECTS AND METHODS: The investigation was conducted using the intraoperative material (resected portions of the large and small bowels, appendix) obtained from 40 women diagnosed as having deep infiltrating endometriosis involving the bowel, which was accompanied by pain syndrome. Paraffin sections were immunohistochemically examined using the standard protocol. Antibodies to Ki-67, PTEN, ER, PR, ("Dako"), CD34 ("Cell Marque", USA), VEGF, EGF, EGFR, COX-2 ("Abcam"), and MMP 1 and 2 ("Abbiotec") were applied. Dako REAL EnVision Detection System kits ("Dako", Denmark) were used as secondary antibodies. RESULTS: The morphological substrate of pelvic pain syndrome in deep infiltrating endometriosis was established to be factors that acted in situ at the location of endometriotic foci and those caused by the infiltrative perivascular, intravascular, and perineural growth of endometrioid heterotopies. CONCLUSION: Inflammation and fibrosis in the endometriotic foci contribute to the accumulation of algogenes, which gives rise to somatogenic pain syndrome, and chronic nerve fiber injury as a source of nociceptive stimulation leads to neuropathic pain syndrome.

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Condition tags

endometriosischronic_pelvic_paindie_deep_infiltrating

MeSH descriptors

Endometriosis Endometriosis Pelvic Pain Pelvic Pain Adult Cell Proliferation Endometriosis Endometriosis Female Gene Expression Regulation Humans Inflammation Inflammation Inflammation Middle Aged Pelvic Pain Pelvic Pain Protein Biosynthesis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (8)

Cited by (11)

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