Deep Dyspareunia in Endometriosis: Role of the Bladder and Pelvic Floor

Natasha L Orr, Heather Noga, Christina Williams, Catherine Allaire, Mohamed A Bedaiwy, Sarka Lisonkova, Kelly B Smith, Paul J Yong
The journal of sexual medicine · 2018 · vol. 15(8) , pp. 1158–1166 · doi:10.1016/j.jsxm.2018.06.007 · PMID:30078464 · W2885787937
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

In women with endometriosis, deep dyspareunia severity was associated with bladder/pelvic floor tenderness and painful bladder syndrome, irrespective of endometriosis stage or specific disease factors.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This observational study used data from a prospective tertiary-centre registry (Jan 2014–Dec 2016) of 411 women aged 18–49 with surgically confirmed, histopathologically validated endometriosis to test whether bladder/pelvic floor tenderness and painful bladder syndrome were associated with pre-operative deep dyspareunia severity, analyzed separately by endometriosis stage (I/II vs III/IV). Deep dyspareunia severity was measured on an 11-point numeric rating scale, and multivariable ordinal logistic regression adjusted for endometriosis-specific factors (e.g., deep infiltrating endometriosis) and other covariates; strengths included prospective design and experienced surgical staging, while a stated limitation was assessment of only one pelvic floor muscle (levator ani). Severity of deep dyspareunia was independently associated with both bladder/pelvic floor tenderness and painful bladder syndrome in women with Stage I/II and showed similar associations in women with Stage III/IV, with reported adjusted odds ratios around ~1.9–2.5. This paper is centrally about endometriosis — it examines how bladder and pelvic floor tenderness and painful bladder syndrome relate to deep dyspareunia severity across endometriosis stages.

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Abstract

INTRODUCTION: The etiology of endometriosis-associated deep dyspareunia may include direct endometriosis-specific factors (eg, stage or invasiveness of disease) and/or indirect contributors such as bladder/pelvic floor dysfunction (eg, related to myofascial mechanisms or nervous system sensitization). AIM: This study aimed to determine whether bladder/pelvic floor tenderness and painful bladder syndrome were associated with severity of deep dyspareunia in women with endometriosis, regardless of Stage (I/II vs III/IV) or other endometriosis-specific factors. METHODS: Observational study from a prospective patient registry (January 2014 to December 2016) at a tertiary centre for endometriosis. Included were women aged 18 to 49 years who had surgical removal and histopathologic confirmation of endometriosis at the centre. Cases with Stage I/II vs Stage III/IV endometriosis were analyzed separately. Bivariate associations with the primary outcome (severity of deep dyspareunia) were tested for bladder/pelvic floor tenderness, painful bladder syndrome, as well as endometriosis-specific factors identified at the time of laparoscopic surgery (eg, deep infiltrating endometriosis) and demographic factors (eg, age). Multivariable ordinal logistic regression was carried out to adjust for factors associated with the primary outcome. MAIN OUTCOME MEASURE: Primary outcome was severity of deep dyspareunia on an 11-point numeric rating scale, categorized as none/mild (0-3), moderate (4-6), and severe (7-10), from a preoperative self-reported questionnaire. RESULTS: Overall, 411 women had surgically confirmed endometriosis: 263 had Stage I/II and 148 had Stage III/IV endometriosis. Among women with Stage I/II endometriosis, severity of deep dyspareunia was associated with both bladder/pelvic floor tenderness and painful bladder syndrome (AOR = 1.94, 95% CI: 1.11-3.38, P = .019 and AOR = 1.99, 95% CI: 1.15-3.44, P = .013, respectively), independent of endometriosis-specific factors or other factors associated with deep dyspareunia severity. Similar associations were found in women with Stage III/IV endometriosis (bladder/pelvic floor tenderness AOR =2.51, 95% CI: 1.25-5.02, P = .01, painful bladder syndrome: AOR = 1.90, 95% CI: 1.01-3.57, P = .048). CLINICAL IMPLICATIONS: Myofascial or nervous system mechanisms may be important for deep dyspareunia in women with endometriosis, even in those with moderate-to-severe disease (Stage III/IV). STRENGTHS & LIMITATIONS: Strengths include the prospective registry, and histological confirmation of endometriosis and staging by experienced endometriosis surgeons. Limitations include assessment of only one pelvic floor muscle (levator ani). CONCLUSION: In women with Stage I/II or Stage III/IV endometriosis, severity of deep dyspareunia was strongly associated with bladder/pelvic floor tenderness and painful bladder syndrome, independent of endometriosis-specific factors, which suggests the role of myofascial or sensitization pain mechanisms in some women with deep dyspareunia. Orr NL, Noga H, Williams C, et al. Deep Dyspareunia in Endometriosis: Role of the Bladder and Pelvic Floor. J Sex Med 2018;15:1158-1166.

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Condition tags

dyspareuniaendometriosisdie_deep_infiltrating

MeSH descriptors

Cystitis, Interstitial Dyspareunia Endometriosis Adolescent Adult Cystitis, Interstitial Cystitis, Interstitial Dyspareunia Dyspareunia Endometriosis Endometriosis Female Humans Laparoscopy Middle Aged Pain Measurement Pelvic Floor Pelvic Floor Prospective Studies Severity of Illness Index

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