Natasha L. Orr

Chronic pelvic pain (CPP) affects ∼15% of women and gender-diverse people, yet it is often dismissed by health care providers, partly due to a lack of related medical education. This brief communication describes the findings of a needs ass…

Trauma-informed approaches can promote the creation of systems that prioritize safety and empowerment to improve patient well-being. These approaches are especially important in sexual and reproductive health care, where patients are often …

Background: The COVID-19 pandemic posed unique challenges for Asian people living with endometriosis. The purpose of this study was to describe the endometriosis-related coping and self-management strategies used by South, East, and Southea…

BACKGROUND: Endometriosis affects approximately 190 million people globally and 2 million in Canada. Experiences of endometriosis can profoundly impact all aspects of life, including physical, mental, and financial well-being. The Coronavir…

Endometriosis is a chronic condition affecting 10% of reproductive aged girls and women globally and an unmeasured number of gender diverse people. Experiences of endometriosis can greatly affect sexual wellbeing, as pain with insertive sex…

UNSTRUCTURED Trauma-informed approaches promote the creation of systems that prioritize safety and empowerment to improve patient well-being. These approaches are especially important in sexual and reproductive healthcare, where patients a…

BACKGROUND: Deep dyspareunia affects 50% of people with endometriosis. The Ohnut is a set of interlocking rings that fit over the penis/insertive object. One or more rings can be used to limit insertion depth and reduce deep dyspareunia. A…

BACKGROUND: Pelvic pain worsened by orgasm is a poorly understood symptom in patients with endometriosis. AIM: To assess the prevalence of pelvic pain worsened by orgasm in patients with endometriosis and explore its association with poten…

STUDY QUESTION: Is there an association between the somatic loss of PTEN (phosphatase and tensin homolog) and ARID1A (AT-rich interaction domain 1A) and endometriosis disease severity and worse clinical outcomes? SUMMARY ANSWER: Somatic PTE…

Abstract Introduction Among individuals with endometriosis, approximately 50% experience deep dyspareunia. There is a validated test to evaluate superficial dyspareunia (tampon test); however, no such test exists for deep dyspareunia. Thus,…

Abstract Introduction Approximately 10% of reproductive-age females are affected by endometriosis, and of those, ~50% suffer from deep dyspareunia (DD). A portion of those with DD do not respond to medical and surgical treatments and theref…

BACKGROUND: Approximately half of people with endometriosis experience deep dyspareunia; however, there is no means of objective self-testing of endometriosis-associated deep dyspareunia. AIM: The aim of this study was to assess the accepta…

Endometriosis-associated dyspareunia can persist after surgical interventions, requiring multidisciplinary treatment including pain education. This study explored the effectiveness of a one-day workshop for improving knowledge, behavioural …

Importance: A subset of people who undergo surgery for endometriosis have persistent pain, suggesting that other factors besides the endometriosis, such as central sensitization, may play a role in this pain. The Central Sensitization Inven…

BACKGROUND: Endometriosis-associated deep dyspareunia is associated with reduced sexual quality of life, lower self-esteem, and impaired sexual function. OBJECTIVE: The primary objective is to assess the acceptability of a phallus length r…

The clinical phenotype of somatic mutations in endometriosis is unknown. The objective was to determine whether somatic KRAS mutations were associated with greater disease burden in endometriosis (i.e. more severe subtypes and higher stage)…

Endometriosis is a common condition in women that causes chronic pain and infertility and is associated with an elevated risk of ovarian cancer. We profiled transcriptomes of >370,000 individual cells from endometriomas (n = 8), endometrios…

Introduction We propose a standardized protocol for measurement of nerve bundle density in endometriosis as a potential biomarker, including in deep endometriosis (DE), ovarian endometriomas (OMA) and superficial peritoneal endometriosis (S…

BACKGROUND Endometriosis-associated deep dyspareunia is associated with reduced sexual quality of life, lower self-esteem, and impaired sexual function. OBJECTIVE The primary objective is to assess the acceptability of a phallus length r…

ABSTRACT Introduction Deep dyspareunia negatively impacts people living with endometriosis and their sexual relationships. We are conducting a pilot study to assess the acceptability of 1) a silicone buffer (brand: OhNut) worn by the penetr…

Abstract Endometriosis is a common, benign condition characterized by extensive heterogeneity in lesion appearance and patient symptoms. We profiled transcriptomes of 207,949 individual cells from endometriomata (n=7), extra-ovarian endomet…