IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis

Nanda Yuli Rahmawati, Fadhil Ahsan, Budi Santoso, Alfin Firasy Mufid, Ashon Sa’adi, Ashon Sa'adi, Sri Ratna Dwiningsih, Arif Tunjungseto, Muhammad Yohanes Ardianta Widyanugraha
Pain medicine (Malden, Mass.) · 2023 · vol. 24(11) , pp. 1262–1269 · doi:10.1093/pm/pnad080 · PMID:37326977 · W4380869530
article OA: closed CC0 ⤵ 14 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that serum IL-8 and IL-12p70 levels correlated with pelvic pain scores in infertile women with endometriosis, with peritoneal IL-1β and IL-6 also showing correlations.

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Abstract

OBJECTIVE: To evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid in women related to infertility and pelvic pain. METHODS: Eighty-seven women were diagnosed with endometriosis or cases related to infertility. IL-1β, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid were determined by enzyme-linked immunosorbent assay (ELISA). Pain assessment was evaluated by the Visual Analog Scale (VAS) score. RESULTS: Serum IL-6 and IL-12p70 levels increased in women with endometriosis compared to the control group. Serum and peritoneal IL-8 and IL-12p70 levels correlated with VAS scores in infertile women. A positive correlation was also found between peritoneal IL-1β and IL-6 with VAS score. A significant difference in peritoneal IL-1β levels was associated with menstrual pelvic pain, while peritoneal IL-8 levels were related to dyspareunia, menstrual, and post-menstrual pelvic pain in infertile women. CONCLUSIONS: An association of IL-8 and IL-12p70 levels were related to pain in endometriosis, as well as a relationship between cytokine expression and VAS score. Further studies should be addressed to investigate the precise mechanism of cytokine-related pain in endometriosis.

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Outcome instruments

VAS-pain

Condition tags

mesh:D004715mesh:D017699endometriosisdyspareuniainfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Infertility, Female Infertility, Female Infertility, Female Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (44)

Cited by (14)

Source provenance

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License: CC0 · commercial use OK