Ashon Sa’adi

INTRODUCTION: Pelvic pain, often associated with endometriosis, significantly affects women's quality of life. This study explored the soluble neural cell adhesion molecules (sNCAM), soluble interleukin 2 receptor α (sIL-2Rα), and IL-2 leve…

Chronic Pelvic Pain (CPP) is defined as persistent pain in the pelvic region that persists for a duration of six months or more. A prevailing cause of CPP is endometriosis, affecting 10-15% of women of reproductive age. The present report d…

INTRODUCTION: Endometriosis is a chronic inflammatory disease characterized by endometrial-like tissue outside the uterus. Molecules linked to natural killer (NK) and cytotoxic T cells, including granulysin (GNLY), MHC class I-related chain…

Introduction: TNF-α, LT-α, and sCD40L belong to the TNF superfamily and play a pivotal role in chronic inflammatory disease. Yet, these soluble molecules are largely unexplored in endometriosis cases with infertility. The present study aime…

OBJECTIVE: To investigate the association between soluble adhesion molecules (sE-cadherin, sE-selectin, sICAM-1, sVCAM-1) in serum and peritoneal fluid and pelvic pain in infertile women with endometriosis. METHODS: This observational study…

Background This study aimed to determine the accuracy of CYFRA 21-1 using urine creatinine correction (CYFRA/Cr) as a biomarker of endometriosis. Methods This study includes 73 patients from the Indonesian population, with 38 endometriosis …

OBJECTIVE: To evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid in women related to infertility and pelvic pain. METHODS: Eighty-seven women were diagnosed with endometriosis or cases related to inf…

Endometriosis is a chronic inflammatory disorder characterized by abnormal endometrial tissue outside the uterine cavity, with a prevalence of 10% worldwide. TNF-α has been implicated in developing endometriosis; however, TNF-α is mainly un…

Background: Women with vitamin D deficiency are at higher risk of having endometriosis. Endometriosis is a benign gynecological disease that occurs in women of reproductive age with multifactorial etiopathogenesis with high migratory and in…

Endometriosis, a painful inflammatory condition, arises from the growth of endometrial tissue beyond the uterus. The anti-inflammatory properties of basil (Ocimum basilicum L.) suggest its potential as a treatment for endometriosis. This st…

Background: As a multi-functional cytokine, interleukin-6 (IL-6) is advanced in endometriosis. Probiotics are known to be able to modulate/regulate immune responses through downregulation of the pro-inflammatory cytokine IL-6. Lactobacillus…

PROBLEM: Soluble immune checkpoint molecules constitute the emerging novel mediators in immune regulation. Their role in the pathogenesis of endometriosis has not been fully addressed. In this study, we aimed to investigate the relationship…

Objectives: to measure and prove the increase of panmacrophage, macrophages M1 and M2 expression and decrease of ratio of M1/M2 in menstrual blood flakes of women with endometriosis. Materials and Methods: This study was a cross sectional o…

Chronic inflamation at endometriosis causing oxidative stree at granulosa cell which cause unbalance between free radical and anti oxidant. This cause the chains effect continuously and cause the destruction of cell membrane and the last ef…

Medical therapy of endometriosis can only be used within a limited time because of arising side effects. One method of medical treatment that was developed for this purpose is using herbal ingredients, the curcumin. The objective of this st…