Differential Expression of Granulysin, MHC Class I-Related Chain A, and Perforin in Serum and Peritoneal Fluid: Immune Dysregulation in Endometriosis-Related Infertility

Fadhil Ahsan, Budi Santoso, Nanda Yuli Rahmawati, Fidyah Nanda Alditia, Alfin Firasy Mufid, Ashon Sa’adi, Ashon Sa'adi, Sri Ratna Dwiningsih, Arif Tunjungseto, M Y Ardianta Widyanugraha
Immunological investigations · 2024 · vol. 54(2) , pp. 234–249 · doi:10.1080/08820139.2024.2431847 · PMID:39589023 · W4404716365
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found elevated serum and peritoneal fluid levels of perforin and MICA in infertile women with endometriosis, suggesting their association with the disease's severity and potential as biomarkers.

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Abstract

INTRODUCTION: Endometriosis is a chronic inflammatory disease characterized by endometrial-like tissue outside the uterus. Molecules linked to natural killer (NK) and cytotoxic T cells, including granulysin (GNLY), MHC class I-related chain A (MICA), and perforin (PRF1) support immune surveillance, though their roles in endometriosis remain unclear. This study investigates the association of these molecules with clinical parameters in infertile women with endometriosis. METHODS: Eighty-seven infertile women undergoing diagnostic laparoscopy were included: 44 with endometriosis and 43 with benign gynecologic disorders. Serum and peritoneal molecules were measured using ELISA. Statistical analyses compared groups and correlated immune markers with clinical parameters. RESULTS: = .008). CONCLUSION: Elevated PRF1 and MICA levels were associated with endometriosis severity, indicating their potential as biomarkers. Future studies should validate this finding and explore its therapeutic role in endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Ascitic Fluid Ascitic Fluid

Citation neighborhood

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References (50)

Source provenance

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