The Role of Serum Caspase 3 Levels in Prediction of Endometriosis Severity

Cihan Kaya, Ismail Alay, Alay I, Hakan Güraslan, Hakan Guraslan, Gedikbasi A, Asuman Gedikbaşı, Asuman Gedikbasi, Murat Ekin, Ertaş Kaya S, Sinem Ertaş Kaya, Engin Oral, Oral E, Yasar L, Levent Yasar, Levent Yaşar
Gynecologic and obstetric investigation · 2018 · vol. 83(6) , pp. 576–585 · doi:10.1159/000489494 · PMID:30071521 · W2885804338
article OA: closed CC0 ⤵ 12 in-corpus citations
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This study found that serum caspase-3, Annexin A2, and soluble Fas Ligand levels were significantly different between endometriosis stages and controls, with caspase-3 showing potential as a predictor of endometriosis severity.

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Abstract

Background/Aims: To identify the role of serum caspase 3, Annexin A2 (ANXA2), and Soluble Fas Ligand (sFasL) levels in the prediction of endometriosis severity. Methods: The study was performed on 90 women who were candidates for laparoscopic surgery due to endometrioma or any other benign ovarian cysts detected by ultrasound examination, pelvic pain, or infertility. The control group comprised 29 patients. The second group comprised 29 patients with stage I–II endometriosis and the third group comprised 30 patients with stage III–IV endometriosis. Results: Significant differences were detected between the control and stage III–IV endometriosis groups and between stage I–II and stage III–IV endometriosis groups in terms of caspase-3 levels (both, p < 0.001), ANXA2 levels (p = 0.007 and p = 0.002), and sFasL levels (p = 0.022 and p = 0.044). After receiver operating characteristic analysis, the area under curve was 93% (95% CI 57–82) at 10.7 ng/mL cut-off level for caspase-3 with 90% sensitivity and 87% specificity. Conclusion: Serum caspase-3 level may be a reliable predictor of endometriosis severity.

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Condition tags

endometriosisendometriomainfertility

MeSH descriptors

Annexin A2 Caspase 3 Endometriosis Fas Ligand Protein Adolescent Adult Annexin A2 Caspase 3 Endometriosis Endometriosis Fas Ligand Protein Female Humans Laparoscopy Middle Aged Prospective Studies ROC Curve Sensitivity and Specificity Young Adult

Citation neighborhood

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License: CC0 · commercial use OK