Expression and clinical significance of Capase3 and C-IAP1/2 in ectopic endometrium of patients with endometriosis

Xiaoyun Zhang, Weiying Zhao
Cellular and molecular biology (Noisy-le-Grand, France) · 2023 · vol. 69(7) , pp. 127–130 · doi:10.14715/cmb/2023.69.7.20 · PMID:37715391 · W4386796108
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Caspase-3 expression was lower and C-IAP1/2 expression was higher in ectopic and eutopic endometrium from endometriosis patients compared to controls, with C-IAP1/2 levels correlating with disease stage.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper investigated expression of Caspase-3 and c-IAP1/2 in ectopic versus eutopic endometrial tissues from women with endometriosis, comparing them with endometrial control tissues from patients without endometriosis, using immunohistochemistry. It found that Caspase-3 expression was significantly lower in both ectopic and eutopic endometrium from endometriosis patients than in controls, while c-IAP1/2 expression was significantly higher in both ectopic and eutopic tissues compared with controls. C-IAP1/2 levels were higher in stage III–IV than in stage I–II, and c-IAP1 positivity in ectopic tissue was negatively correlated with Caspase-3 positivity in ectopic tissue. The study’s limitation is that, beyond stage association, it does not provide additional mechanistic or causal analyses to confirm how these expression differences drive clinical outcomes. This paper is centrally about endometriosis — it examines Caspase-3 and c-IAP1/2 expression in ectopic and eutopic endometrium and relates c-IAP1/2 to disease stage.

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Abstract

To analyze the expression of capase3 and C-IAP1/2 in endometriosis and their relationship with clinical practice. Ectopic and eutopic endometrial tissues were collected from women with endometriosis, and the control tissues were obtained from regular patients without endometriosis. The expression level of capase3 and C-IAP1/2 was detected by immunohistochemistry; in addition, the relationship between C-IAP1/2 expression and the clinical stage of endometriosis was analyzed. The expression of Caspase-3 in ectopic and eutopic endometrium was significantly lower than that in the control group (P < 0.005). The expression of C-IAP1/2 in ectopic and situ endometrium was significantly higher than in the control group (P < 0.005). The expression of C-IAP1/2 in stage III-IV was higher than in stage I-II endometriosis. The positive expression of c-IAP1 protein in ectopic endometrial tissue was negatively correlated with the positive expression of Caspase-3 protein in ectopic endometrial tissue (P<0.001). The low expression of Caspase-3 and the high expression of C-IAP1/2 in the ectopic endometrium and eutopic endometrial tissues compared with the controls. The results indicated that the apoptotic ability of eutopic and ectopic endometrium is weakened, which is involved in the pathogenesis of endometriosis. It is expected to be a target for the diagnosis and therapy of this disease. At the same time, the expression level of C-IAP1/2 is related to the stage of endometriosis, which can guide clinical treatment.

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Condition tags

endometriosis

MeSH descriptors

Choristoma Choristoma Choristoma Choristoma Choristoma Choristoma Choristoma Choristoma Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Caspase 3 Caspase 3 Caspase 3

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