Biomarkers of Pelvic Endometriosis

Cecília de Souza Monteiro, Fernando Marcos Dos Reis, Márcia Mendonça Carneiro, Fernando M. Reis
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2017 · vol. 39(03) , pp. 091–093 · doi:10.1055/s-0037-1601398 · PMID:28359109 · W2597658127
editorial OA: diamond CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis, characterized by pelvic pain and infertility, often goes undiagnosed for years due to nonspecific symptoms, negatively impacting patients' quality of life.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This editorial discusses the search for non-invasive biomarkers for pelvic endometriosis, reviewing prior work on serum/plasma markers and imaging limitations, and highlighting emerging molecular approaches such as high-throughput sequencing and proteomics. It notes that no endometriosis-specific antigen has been found and that many candidate serum markers have low sensitivity due to nonspecific systemic biochemical features and menstrual-cycle variation; a referenced Cochrane review found that none of 141 evaluated studies produced biomarkers accurate enough for daily practice, with only limited meta-analytic support for markers like CA-125 and interleukin-6. The paper emphasizes that translation from bench to bedside remains limited by the need for systematic candidate selection, rigorous validation, and testing in symptomatic populations with unknown diagnoses. This paper is centrally about endometriosis — it focuses on the state of biomarker discovery and validation for non-invasive detection of pelvic endometriosis.

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Abstract

Endometriosis is typically a symptomatic disease, and the symptoms often manifest as dysmenorrhea, dyspareunia, chronic pelvic pain, and/or infertility. Deep infiltrating endometriosis can also produce cyclic urinary or intestinal complaints. Nevertheless, the symptoms of endometriosis are not specific, and may be associated with many other different conditions. Severe dysmenorrhea in adolescent girls may be underestimated by health care providers and accepted as a physiological fate. Thus, patients can spend years without the accurate diagnosis and the proper treatment, with a tremendous negative impact on their quality of life.[1]

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Condition tags

mesh:D004715endometriosisdie_deep_infiltratingchronic_pelvic_paindysmenorrheadyspareuniainfertility

MeSH descriptors

Endometriosis Biomarkers Biomarkers Endometriosis Female Humans Pelvis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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