Sri Ratna Dwiningsih

Endometriosis, a chronic inflammatory condition linked to pelvic pain and infertility, is characterized by immune dysfunction involving dysregulated apoptosis and cell proliferation. This case-control study included 87 infertile women under…

BACKGROUND Women with endometriosis experience significantly reduced fertility, potentially linked to mitochondrial dysfunction. This study investigates the impact of endometriosis on oocyte mitochondrial morphology and cardiolipin levels, …

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissues (glands and stroma) located outside the uterine cavity. The pathophysiology of this condition remains incompletely understood. Local b…

Background: The goals of endometriosis treatment vary greatly depending on the patient's symptoms and reproductive needs. Hormonal therapy to alleviate pain has generally been shown to have positive effects. Combined Oral Contraceptives (CO…

INTRODUCTION: Pelvic pain, often associated with endometriosis, significantly affects women's quality of life. This study explored the soluble neural cell adhesion molecules (sNCAM), soluble interleukin 2 receptor α (sIL-2Rα), and IL-2 leve…

BACKGROUND: This study aimed to determine the accuracy of CYFRA 21-1 using urine creatinine correction (CYFRA/Cr) as a biomarker of endometriosis. METHODS: This study includes 73 patients from the Indonesian population, with 38 endometrios…

Chronic Pelvic Pain (CPP) is defined as persistent pain in the pelvic region that persists for a duration of six months or more. A prevailing cause of CPP is endometriosis, affecting 10-15% of women of reproductive age. The present report d…

Introduction: Endometriosis is a gynecological problem which is one of the main causes of secondary dysmenorrhea with pathological conditions. Endometriosis is defined as a disorder characterized by the presence of tissue similar to the end…

Introduction: Ovarian endometrioma has a significantly high recurrence rate after surgery. Postoperative hormonal therapy may be useful in preventing recurrence. This study assesses recurrence rates, timing, and risk factors for patients wi…

Infertility, defined as the inability to conceive after one year of unprotected intercourse (WHO, 2012), affects 8–10% of couples worldwide, equivalent to 50–80 million couples, with 2 million new cases annually (WHO, 2013). In Indonesia, 1…

INTRODUCTION: Endometriosis is a chronic inflammatory disease characterized by endometrial-like tissue outside the uterus. Molecules linked to natural killer (NK) and cytotoxic T cells, including granulysin (GNLY), MHC class I-related chain…

Introduction: TNF-α, LT-α, and sCD40L belong to the TNF superfamily and play a pivotal role in chronic inflammatory disease. Yet, these soluble molecules are largely unexplored in endometriosis cases with infertility. The present study aime…

OBJECTIVE: To investigate the association between soluble adhesion molecules (sE-cadherin, sE-selectin, sICAM-1, sVCAM-1) in serum and peritoneal fluid and pelvic pain in infertile women with endometriosis. METHODS: This observational study…

OBJECTIVES: Myeloid cell-derived factors contribute to the immunopathology of endometriosis. Soluble CD14 (sCD14), CD163 (sCD163), and MIF serve as in vivo markers of myeloid function. However, these soluble molecules are largely unexplored…

Background This study aimed to determine the accuracy of CYFRA 21-1 using urine creatinine correction (CYFRA/Cr) as a biomarker of endometriosis. Methods This study includes 73 patients from the Indonesian population, with 38 endometriosis …

OBJECTIVE: To evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid in women related to infertility and pelvic pain. METHODS: Eighty-seven women were diagnosed with endometriosis or cases related to inf…

Endometriosis is a chronic inflammatory disorder characterized by abnormal endometrial tissue outside the uterine cavity, with a prevalence of 10% worldwide. TNF-α has been implicated in developing endometriosis; however, TNF-α is mainly un…

Background: Since endometriosis causes a decrease in oocyte quality, the success rate of in vitro fertilization cycles decreases. The purpose of the current study was to analyze the effect of endometriosis on intracellular calcium levels, C…

Background: Endometriosis is an estrogen-dependent chronic progressive gynecological dis-ease that affects around 10% of women of reproductive age. A recent study shows that brain-derived neurotrophic factor (BDNF) has the potential as a cl…

Background. In endometriosis, there is an increase in ROS levels and can cause a damage the DNA structures. Objectives. To analyze the effect of mesenchymal stem cells on the expression of BCl2 mRNA, p21 mRNA, and Survivin mRNA in mice with…

BACKGROUND AND AIM: Endometriosis affects the ovaries and causes a decrease in the oocyte quality during endometrial receptivity. During the development of ovarian follicles, paracrine communication occurs between granulosa cells and oocyte…

PROBLEM: Soluble immune checkpoint molecules constitute the emerging novel mediators in immune regulation. Their role in the pathogenesis of endometriosis has not been fully addressed. In this study, we aimed to investigate the relationship…

Objectives: To determine the effect of bone marrow mesenchy-mal stem cells (BMSCs) on BMP-15 expression and Graafian follicle count in endometriosis mice.Material and Methods: This study was a laboratory randomized clinical trial on Mus mus…