Brain Derived Neurotrophic Factor as a Non-invasive Biomarker for Detection of Endometriosis

Dwiningsih SR, Sri Ratna Dwiningsih, Christina Meilani, Meilani C, Hadi S, Samsul Hadi
Journal of reproduction & infertility · 2022 · vol. 23(3) , pp. 207–212 · doi:10.18502/jri.v23i3.10012 · PMID:36415495 · PMC9666593 · W4285029145
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Serum brain-derived neurotrophic factor levels were higher in women with endometriosis and moderately correlated with pain scores, but demonstrated low diagnostic accuracy.

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This paper evaluates brain-derived neurotrophic factor (BDNF) as a non-invasive biomarker for detecting endometriosis, focusing on measuring BDNF in a non-invasive setting rather than using invasive diagnostic approaches. It presents BDNF’s potential diagnostic utility in the context of endometriosis detection. The paper’s explicit methodological limitations are not provided in the supplied text, which makes it difficult to assess study design details such as sample composition, assay approach, and statistical performance. This paper is centrally about endometriosis — it specifically investigates BDNF as a non-invasive biomarker for detection of endometriosis.

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Abstract

BACKGROUND: Endometriosis is an estrogen-dependent chronic progressive gynecological disease that affects around 10% of women of reproductive age. A recent study shows that brain-derived neurotrophic factor (BDNF) has the potential as a clinical marker in the diagnosis of endometriosis. We aimed to determine whether BDNF levels are correlated with pain scores associated with endometriosis. METHODS: Fifty women who underwent laparoscopy surgery at Dr. Soetomo General Hospital and Dr. Ramelan Navy Hospital were prospectively recruited from October 2017 until August 2018. A blood sample was obtained before surgery and BDNF was measured using the Human BDNF Quantakine® kit. The relationship of BDNF levels in serum with the diseases's level of pain and stages was compared between cases and controls. BDNF validity as an endometriosis diagnosis biomarker was assessed using receiver operating characteristic (ROC) analysis. RESULTS: Serum concentrations of BDNF were significantly greater in women with endometriosis (30.42±7.41 pg/ml), compared to controls (25.66±3.30 pg/ml). Serum concentrations of BDNF were moderately correlated with the patient's reported pain scores (r=0.44, p=0.01). Receiver operating characteristic curve analysis confirmed the potential of BDNF in the diagnosis of endometriosis. Using a cut-off value of 27.06 pg/ml, the sensitivity and specificity were reported to be 66.7% and 64.3%, respectively. CONCLUSION: BDNF serum levels in endometriosis women are significantly higher than in women without the disorder. BDNF serum level seems to have low accuracy and predictive value as a diagnostic marker for endometriosis. However, there was a moderate relationship between BDNF serum level and the degree of pain.
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Publication Journal of Reproduction & Infertility Record type Journal article Published 11 July 2022 Authors Sri Ratna Dwiningsih | Christina Meilani | Samsul Hadi The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/jri.v23i3.10012', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'Journal of Reproduction & Infertility', 'primary-resource': 'https://publish.kne-publishing.com/index.php/JRI/article/view/10012', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://www.jri.ir/article/120150', 'tld': 'jri.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://publish.kne-publishing.com/index.php/JRI/article/view/10012', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '11 July 2022', 'publication': 'Journal of Reproduction & Infertility', 'title': 'Brain Derived Neurotrophic Factor as a Non-invasive Biomarker for Detection of Endometriosis', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/jri.v23i3.10012', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Sri Ratna Dwiningsih | Christina Meilani | Samsul Hadi', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/jri.v23i3.10012 JSON XML

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endometriosis

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