Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling pathway

Fangzheng Dong, Dong F, Qiyao Zhang, Zhang Q, Kong W, Wei Kong, Chen J, Jun Chen, Ma J, Junlan Ma, Li Wang, Wang L, Yanian Wang, Wang Y, Liu Y, Yan Liu, Li Y, Yan Li, Ji Wen, Wen J
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017 · vol. 33(6) , pp. 485–489 · doi:10.1080/09513590.2017.1295439 · PMID:28277116 · W2598085949
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Estrogen-induced BDNF signaling, involving STAT3, promotes endometrial cell proliferation, with the Val66Met polymorphism acting as a loss-of-function variant.

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Abstract

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth factors family. Recent studies indicated that the level of BDNF in follicular fluid is a marker for oocyte quality and infertility. Here, we intend to further investigate the function of BDNF and its signaling pathway in the regulation of endometrial cells proliferation. We found that BDNF is a critical growth factor in endometrial cells. Activation of signal transducer and activator of transcription 3 signaling pathway is required for BNDF-regulated endometrial cell proliferation. Furthermore, BDNF is an effector of estrogen in endometrial cells. Finally, we investigated the different role of Val66Met, a single-nucleotide polymorphism of the BDNF gene, in regulating endometrial cells proliferation. The results showed that BDNFV66M polymorphism is a loss-of-function polymorphism in the regulation of endometrial cells growth. Given the correlation between endometriosis and infertility, it is important to understand the role of BDNF in regulating endometrial cells proliferation and to develop new therapeutic strategies for the treatment of endometriosis-related infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Brain-Derived Neurotrophic Factor Cell Proliferation Endometrium Brain-Derived Neurotrophic Factor Cell Line, Tumor Endometrium Estrogens Estrogens Female Humans Loss of Function Mutation Polymorphism, Genetic Signal Transduction STAT3 Transcription Factor STAT3 Transcription Factor

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