Nerve fibers and histopathology of endometriosis-harboring peritoneum
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This paper examined the nerve fibers and histopathology of peritoneal tissue from women with endometriosis to understand the underlying tissue changes.
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Abstract
STUDY OBJECTIVE: To evaluate the presence of nerve fibers and histopathology of normal peritoneum and endometriosis-harboring peritoneum.
DESIGN: Prospective, nonrandomized study (Canadian Task Force classification II-1).
SETTING: University hospital.
MATERIALS: Peritoneal specimen from 40 women with laparoscopic findings of endometriosis (24 confirmed histopathologically, group H, 16 diagnosed by laparoscopy, group L) and from 9 women with no endometriosis (controls).
INTERVENTION: Histopathologic examination of peritoneal specimens with nerve fibers identified by immunocytochemistry staining with an antibody to neurofilament.
MEASUREMENTS AND MAIN RESULTS: No differences in mean nerve score were seen among the three groups. Degrees of lymphocytic infiltration and mesothelial hyperplasia were higher in group H than in the other two groups (p <0.01 and <0.05, respectively). The degree of lymphocytic infiltration was significantly higher in group L than in the control group (p <0.05). There were no differences in all measurements between women in group H who experienced chronic pelvic pain and those who did not.
CONCLUSION: The presence of nerve fibers in peritoneum is not related to endometriosis. Endometriosis-harboring peritoneum contains more lymphocytic infiltration than normal peritoneum. (J Am Assoc Gynecol Laparosc 8(1):95-98, 2001)
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- W6717191806 via openalex
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- IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis 2023
- The role of peripheral nerve signaling in endometriosis 2021
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- The Relationship between Serum Levels of Oxidative Stress Biomarkers and Dysmenorrhea, Dyspareunia and Pelvic Pain in Women with Endometriosis 2020
- Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications 2020
- A Proposed Platform for Phenotyping Endometriosis-Associated Pain: Unifying Peripheral and Central Pain Mechanisms 2020
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- Nerve fibre infiltration and expression in peritoneal lesions of endometriosis in a nonhuman primate model of endometriosis 2018
- Evaluation of the sacral nerve plexus in pelvic endometriosis by three-dimensional MR neurography 2016
- The structure, nature and intensity of painin various forms of external genital endometriosis 2016
- Chronic pelvic pain: Pathogenesis and validated assessment 2016
- Nerve fibers and endometriotic lesions: partners in crime in inflicting pains in women with endometriosis 2016
- Pain typology and incident endometriosis 2015
- Pathogenetic Mechanisms of Deep Infiltrating Endometriosis 2015
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- Does the uterine cervix become abnormally reinnervated after subtotal hysterectomy and what is the association with future trachelectomy? 2014
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- Induction of the neurokinin 1 receptor by TNFα in endometriotic tissue provides the potential for neurogenic control over endometriotic lesion growth 2013
- Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis 2011
- Regulatory T cells and other leukocytes in the pathogenesis of endometriosis 2011
- Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications 2010
- Mysteries of endometriosis pain: Chien-Tien Hsu Memorial Lecture 2009 2010
- Endometriosis-associated nerve fibers and pain 2009
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- Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis 2008
- Physiopathologie de l'endométriose 2008
- A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions 2008
- Rich innervation of deep infiltrating endometriosis 2008
- Gynecological Pain, Endometriosis, Visceral Disease, and the Viscero-Somatic Connection 2008
- Microanatomy and function of the eutopic endometrium in women with endometriosis 2008
- Endometriosis and Adenomyosis 2007
- Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis 2007
- Nerve fibres in peritoneal endometriosis 2006
- Quality of sex life in women with endometriosis and deep dyspareunia 2005
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