Endometriosis-associated Pain in Patients with and without Hormone Therapy

Iris Brandes, Mandala Neuser, Andreas Köpf, Vito Chiàntera, Jalid Sehouli, Sylvia Mechsner
In: Journal of Endometriosis and Pelvic Pain Disorders · 2017 · vol. 9(3) , pp. 200–205 · doi:10.5301/jeppd.5000286 · W2619738189
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that while hormone therapy showed a non-significant trend toward reducing cyclic endometriosis pain, it was associated with increased incidence and intensity of non-cyclic pain.

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Abstract

Introduction Endometriosis is associated with both cyclic and non-cyclic pelvic pain. Many patients do not remain symptom free, even after guideline-oriented treatment. This study aimed to identify differences in endometriosis-associated pain and test for possible associations with hormone therapy. Methods The results presented here are based on a cross-sectional study conducted at the Charité Endometriosis Center in Berlin in which pain profile data were collected via a questionnaire from women with a confirmed diagnosis of endometriosis. The questionnaire contained items concerning cyclic and non-cyclic pain, pain intensity, and pain duration. SPSS software was used to perform the statistical analysis, including descriptive and analytical statistics. Results Of 239 women surveyed, 121 (50.6%) reported current hormone therapy, and 185 (77.4%) reported previous hormone therapy. Moreover, 84% had current (cyclic and non-cyclic) pain symptoms, which were severe enough to warrant treatment in nearly 70% of all cases. Hormone therapy was only found to be associated with a slight, non-significant advantage in patients with “cyclic pain”. The reverse was true of non-cyclic pain: women on hormone therapy reported a greater incidence of pain, greater pain intensity, more frequent need for treatment, and more pain days. Conclusions With a very broad interpretation of our findings, it can be concluded that hormone therapy achieves some degree of pain reduction via down-regulation of the ovarian cycle, at least in the case of cyclic pain, whereas non-cyclic pain does not respond or no longer responds to hormones.

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endometriosis

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