Integration of Bioinformatics and Pharmacological Network for Exploring the Potential of Curcumin as a Herbal Medicine for Adenomyosis

Nastiti Mayangsari, Darmawi Darmawi, Muhammad Yusuf, S Donel, Wiwin Suhandri, Wirawan Adikusuma, Suyanto Suyanto, Neni Frimayanti, Rifia T. Fani, Renato Fani
In: Tropical Journal of Natural Product Research · 2025 · vol. 9(9) · doi:10.26538/tjnpr/v9i9.35 · W4414640259
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study used bioinformatics and pharmacological networks to identify EPHA5, EPHB2, and EPHA4 as key targets for curcumin's potential therapeutic effects in adenomyosis, with axon guidance implicated as a key pathway.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text ⓘ

The paper uses an integrated bioinformatics and pharmacological network approach to investigate curcumin, a plant-derived compound, as a potential therapeutic agent for adenomyosis. Using pharmacological network data, protein–protein interaction networks (STRING) and hub-gene identification (CytoHubba) highlighted EPHA5, EPHB2, and EPHA4 as top nodes, while compound–target–disease interaction analysis and GO/KEGG enrichment implicated the axon guidance pathway as significantly enriched. Molecular docking was used to assess stable binding affinities between curcumin and target proteins, providing theoretical and experimental evidence. The main caveat is that the work is based on in silico network/database integration and docking rather than clinical validation, so mechanistic implications require further exploration. This paper is centrally about endometriosis and/or adenomyosis — it is specifically focused on adenomyosis and proposes curcumin’s targets and pathways for this condition.

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Abstract

Adenomyosis is a benign gynecological disorder characterized by abnormal uterine bleeding, infertility, and dysmenorrhea, affecting approximately 10% of women worldwide during their reproductive years. The high morbidity and postoperative complications associated with surgical treatments have generated interest in conservative therapies. Natural medicine, particularly plant-based compounds, is increasingly recognized in the field of reproductive health. Curcumin, a bioactive component found in Indonesian medicinal plants, demonstrates potential as a therapeutic candidate for adenomyosis. This study aimed to explore the physicochemical characteristics, suitable targets, and pharmacological mechanisms of curcumin’s action as a potential therapeutic alternative for adenomyosis. Pharmacological networks integrated with bioinformatics databases was used to explore curcumin’s potential pharmacological targets and mechanisms as an alternative therapy for adenomyosis. Data integration identified shared therapeutic targets, with protein-protein interaction (PPI) networks constructed via the STRING database. CytoHubba analysis identified key hub genes based on connectivity, highlighting EPHA5, EPHB2, and EPHA4 as the top nodes of interest within the PPI network. Compound-target-disease interactions analysis highlighted the therapeutic relevance of curcumin and its impact on adenomyosis-related molecular pathways. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses identified axon guidance as a significantly implicated pathway in adenomyosis. Molecular docking confirmed curcumin’s stable binding affinities with target proteins. This study presents theoretical and experimental evidence supporting curcumin’s potential as a therapeutic agent for adenomyosis. Key molecular targets and pathways are highlighted for further exploration, contributing to a broader understanding of curcumin’s pharmacological profile and its potential as a non-surgical therapy in adenomyosis. 
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Integration of Bioinformatics and Pharmacological Network for Exploring the Potential of Curcumin as a Herbal Medicine for Adenomyosis DOI: https://doi.org/10.26538/tjnpr/v9i9.35Keywords: Pharmacological network, Medicinal plants, Curcumin, Bioinformatics, AdenomyosisAbstract Adenomyosis is a benign gynecological disorder characterized by abnormal uterine bleeding, infertility, and dysmenorrhea, affecting approximately 10% of women worldwide during their reproductive years. The high morbidity and postoperative complications associated with surgical treatments have generated interest in conservative therapies. Natural medicine, particularly plant-based compounds, is increasingly recognized in the field of reproductive health. Curcumin, a bioactive component found in Indonesian medicinal plants, demonstrates potential as a therapeutic candidate for adenomyosis. This study aimed to explore the physicochemical characteristics, suitable targets, and pharmacological mechanisms of curcumin’s action as a potential therapeutic alternative for adenomyosis. Pharmacological networks integrated with bioinformatics databases was used to explore curcumin’s potential pharmacological targets and mechanisms as an alternative therapy for adenomyosis. Data integration identified shared therapeutic targets, with protein-protein interaction (PPI) networks constructed via the STRING database. CytoHubba analysis identified key hub genes based on connectivity, highlighting EPHA5, EPHB2, and EPHA4 as the top nodes of interest within the PPI network. Compound-target-disease interactions analysis highlighted the therapeutic relevance of curcumin and its impact on adenomyosis-related molecular pathways. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses identified axon guidance as a significantly implicated pathway in adenomyosis. Molecular docking confirmed curcumin’s stable binding affinities with target proteins. This study presents theoretical and experimental evidence supporting curcumin’s potential as a therapeutic agent for adenomyosis. Key molecular targets and pathways are highlighted for further exploration, contributing to a broader understanding of curcumin’s pharmacological profile and its potential as a non-surgical therapy in adenomyosis. Downloads References Published Issue Section License Copyright (c) 2025 Tropical Journal of Natural Product Research This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Condition tags

adenomyosisdysmenorrheainfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (44)

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