KORELASI EKSPRESI IMMUNOSITOKIMIA VASCULAR ENDOTHELIAL GROWTH FACTOR A (VEGF A) DENGAN PROTEIN GENE PRODUCT 9,5 (PGP 9,5) DARAH HAID PADA PATOFISIOLOGI ENDOMETRIOSIS

Dedy Hendry, Tita Husnitawati Madjid, Ruswana Anwar, Anita Rachmawati
In: Andalas Obstetrics And Gynecology Journal · 2019 · vol. 1(1) , pp. 38–46 · doi:10.25077/aoj.1.1.38-46.2017 · W3083793453
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found significant differences in VEGF-A and PGP 9.5 expression in eutopic menstrual blood endometrium between endometriosis and non-endometriosis groups, with a positive correlation between VEGF-A and PGP 9.5 in endometriosis patients.

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Abstract

Terdapat perubahan fenotip molekuler endometrium eutopik pada endometriosis berupa perubahan ekspresi gen, respon terhadap hormone steroid, peningkatan marker inflamasi dan molekul adesi seluler, penurunan indeks apoptosis dan kapasitas desidualisasi, peningkatan marker stress oksidatif, peningkatan aktifitas angiogenesis dan neurogenesis. Penelitian dilakukan untuk menganalisis perbedaan ekspresi faktor angiogenesis (VEGF-A) dan faktor neurogenesis (PGP 9,5) endometrium eutopik darah haid antara penderita endometriosis dengan non endometriosis serta korelasi kedua faktor tersebut. Penelitian ini merupakan penelitian potong silang yang menelaah hubungan antara kejadian endometriosis dengan faktor resiko berupa ekspresi VEGF dan PGP 9,5 didalam darah haid. Terdapat perbedaaan yang bermakna ekspresi immunositokimia VEGF A endometrium eutopik darah haid antara kelompok endometriosis dan non endometeriosis (p=0,002). Terdapat perbedaan yang signifikan ekspresi VEGF A dan PGP 9,5 endometrium eutopik darah haid antara kelompok endometriosis dan non endometriosis. Terdapat korelasi positif antara ekspresi VEGF A dengan PGP 9,5 endometrium eutopik darah haid penderita endometriosis.Kata kunci : endometrium eutopik, darah haid, ekspresi VEGF A, ekspresi PGP 9,5, immunositokimia

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (12)

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