Endometriosis: A Mysterious Disease

In: Endometriosis · 2014 · pp. 3–6 · doi:10.1007/978-4-431-54421-0_1 · W206682385
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This book chapter provides a compendium of current understanding regarding endometriosis pathogenesis and its application in therapies, compiling contributions from international scientists.

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This chapter provides a compendium of the current understanding of endometriosis pathogenesis and how that knowledge may be applied to current therapies, authored by an editor who assembled an international set of scientists to contribute chapters. It reviews the historical development of major concepts, including Sampson’s 1927 retrograde menstruation hypothesis for peritoneal endometriosis, and situates ongoing research across basic science and clinical aspects. The chapter’s limitation is that it is an edited overview rather than an original study with its own data collection and results. This paper is centrally about endometriosis — it is a book chapter synthesizing knowledge on endometriosis pathogenesis and therapeutic implications.

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Abstract

Endometriosis is an enigmatic disease, despite a long history of research into its basic science and clinical aspects. Sampson published his pioneer article in 1927, theorizing that retrograde menstruation may cause peritoneal endometriosis. Since that time, researchers throughout the world have wrestled with the mysteries of the disease. In this book, we bring you a compendium of the present understanding of the pathogenesis of endometriosis as well as how this information may be applied in current therapies. As editor, I invited an international group of distinguished scientists to contribute a chapter and was happy that all graciously agreed to do so. Our hope is that this book will provide useful information and fresh knowledge to all doctors and scientists interested in endometriosis, and that it will stimulate further research, and lead to more efficacious treatment modalities. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Sampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422–69. Peterson CM, Johnstone EB, Hammoud AO, Stanford JB, Varner MW, Kennedy A, Chen Z, Sun L, Fujimoto VY, Hediger ML, Buck Louis BM. Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO study. Am J Obstet Gynecol. 2013;208:451. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24:235–58. Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Ann N Y Acad Sci. 2008;1127:106–15. Redwine DB. Was Sampson wrong? Fertil Steril. 2002;78:686–93. Harada T, Iwabe T, Terakawa N. Role of cytokines in endometriosis. Fertil Steril. 2001;76:1–10. Iba Y, Harada T, Horie S, Deura I, Iwabe T, Terakawa N. Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor alpha and interleukin-8 expression. Fertil Steril. 2004;82:1036–42. Takenaka Y, Taniguchi F, Miyakoda H, Takai E, Terakawa N, Harada T. Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cell via induction of cyclooxygehase-2 expression. Fertil Steril. 2010;93:325–7. Lee B, Du H, Taylor HS. Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium. Biol Reprod. 2009;80:79–85. Santamaria X, Massasa EE, Taylor HS. Migration of cells from experimental endometriosis to the uterine endometrium. Endocrinology. 2012;153:5566–74. Sharpe KL, Vernon MW. Polypeptides synthesized and released by rat ectopic uterine implants differ from those of the uterus in culture. Biol Reprod. 1993;48:1334–40. Machado DE, Berardo PT, Palmero CY, Nasciutti LE. Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer disease. J Exp Clin Cancer Res. 2010;29:4. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2014 Springer Japan About this chapter Cite this chapter Harada, T. (2014). Endometriosis: A Mysterious Disease. In: Harada, T. (eds) Endometriosis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54421-0_1 Download citation DOI: https://doi.org/10.1007/978-4-431-54421-0_1 Published: Publisher Name: Springer, Tokyo Print ISBN: 978-4-431-54420-3 Online ISBN: 978-4-431-54421-0 eBook Packages: MedicineMedicine (R0)

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endometriosis

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