Phthalate-treated endometrial cancer cell lines show increased AKR1C1 expression

Endometriosis is common benign gynecologic endometrial disorder that causes infertility and pelvic pain. Endometriosis is associated with aberrant inflammatory responses, increased production of prostaglandins, and progesterone resistance. Recently, aldo-keto reductases (1B and 1C) were shown to play an important role in metabolism of prostaglandins and progesterone. In this study, we assessed the aldo-keto reductase gene expression in endometrial cancer cells (ECC)-1 that were treated with phthalate, which has been previously shown to mediate the development of gynecological disorders. The data indicated that phthalate increased expression of aldo-keto reductases in endometrial cells and stimulated production of prostaglandins and may be involved in the development of progesterone resistance. Similar content being viewed by others

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