PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis

Ulrich Karck, U. Karck, Karck U, F Reister, Frank Reister, Reister F, W Schäfer, Schäfer W, Wolfgang Schdfer, Zahradnik Hp, Hans-Peter Zahradnik, H. P. Zahradnik, M. Breckwoldt, Breckwoldt M
Prostaglandins · 1996 · vol. 51(1) , pp. 49–60 · doi:10.1016/0090-6980(95)00159-x · PMID:8900443 · W1979401373
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This study investigated the release of PGE2 and PGF2α prostaglandins by human peritoneal macrophages, a key factor in endometriosis.

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Abstract

OBJECTIVE: To test for differences in the amount and activity of peritoneal macrophages present in the peritoneal fluid of women with, and without endometriosis using prostaglandin release by macrophages in culture as a marker. PATIENTS: Women of reproductive age undergoing laparoscopy for infertility or chronic pelvic pain with postoperative diagnosis of endometriosis and women undergoing laparoscopy for sterilization. METHODS: Peritoneal fluid was aspirated during laparascopy, volume was recorded, macrophages were isolated via a Ficoll Paque gradient and kept in primary culture. PGE2 and PGF2 alpha release of the cells were measured before and after stimulation with zymosan. RESULTS: Women with endometriosis had significantly more peritoneal macrophages than controls. Peritoneal macrophages of women with endometriosis released significantly more PGE2 than those of the control group: 8.4 +/- 2.0 versus 1.4 +/- 0.4 ng/ml/10(6) cells (mean +/- SEM, p = 0.0005) and PGF2 alpha: 10 +/- 4.3 (endometriosis) versus 1.8 +/- 0.4 (control) ng/ml/10(6) cells (mean +/- SEM, p = 0.045). CONCLUSION: There is a significant increase in the amount of prostaglandins released by peritoneal macrophages from women with endometriosis. These prostaglandins might alter uterine and tubal contractility, thereby affecting fertility.

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Condition tags

endometriosis

MeSH descriptors

Dinoprost Dinoprostone Endometriosis Macrophages, Peritoneal 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Dinoprost Dinoprost Dinoprostone Dinoprostone Dinoprostone Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (32)

Cited by (50)

Source provenance

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License: CC0 · commercial use OK