ObjectiveTo compare the effects of chlormadinone acetate (CMA), dienogest (DNG) and drospirenone (DRSP) on prostaglandin biosynthesis in a human endometrial explants model.Study designHuman endometrial explants obtained by aspiration curett…
Cytochrome P450 metabolism of arachidonic acid (AA) was investigated in human peritoneal macrophages which play a central role in chronic pelvic diseases in women (for example in endometriosis). The formation of eicosanoids other than prost…
ObjectiveTo test for differences in the amount and activity of peritoneal macrophages present in the peritoneal fluid of women with, and without endometriosis using prostaglandin release by macrophages in culture as a marker.PatientsWomen o…
The widening effect of Sulproston 500 microgram IM on the cervix uteri was investigated in a double-blind study conducted in 50 non-pregnant volunteers. In women in the postmenopausal stage who had been given Sulproston, resistance-free wid…
Clinical findings suggest a relationship between prostaglandins of the F2a group progesterone and dysmenorrhea. The menstrual flow of 5 dysmenorrhoic women aged 20-30 years was collected 2 cycles with and 2 cycles without local intrauterine…
The paper reports on intravenous and intrauterine application of Prostaglandin F2alpha and its 15-methyl derivative for the treatment of severe uterine bleedings in obsteterics and gynaecology. The effectiveness of the compounds is demonstr…