The Mechanism Research of Chronic Pelvic Pain

宇凤 沈
In: Advances in Clinical Medicine · 2017 · vol. 07(02) , pp. 130–136 · doi:10.12677/acm.2017.72021 · W2628119351
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Chronic pelvic pain arises from nerve conduction processes triggered by mechanical stress and inflammation, with neuropeptides also playing a role in its regulation.

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This review article examines the pathophysiological mechanisms underlying chronic pelvic pain, identifying mechanical pressure and inflammatory stimulation as primary drivers of nociceptive nerve conduction. It further details how neuropeptides modulate this pain transmission process within the complex etiology that includes conditions like endometriosis, pelvic inflammatory disease, and pelvic organ prolapse. The authors synthesize existing literature to highlight the roles of specific inflammatory cytokines and neurotrophic factors in sustaining chronic pain states. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

慢性盆腔疼痛是妇科的常见病、多发病，病因复杂，诊断困难，常见疾病有子宫内膜异位症、盆腔炎性疾病、盆腔脏器脱垂、尾骨痛等。疼痛是一种伤害性感受，慢性盆腔疼痛的发生是疼痛神经传导的过程，机械压力和炎症的刺激是慢性盆腔疼痛产生的主要原因，在疼痛的神经传导过程中，神经肽类物质也参与慢性疼痛的调控。 Chronic pelvic pain (CPP) is a common and frequent gynaecological disease, whose etiology is complex, difficult to diagnosed and involves diseases of multiple systems, common diseases such as endometriosis, pelvic inflammatory disease, interstitial cystitis, irritable bowel syndrome and pelvic organ prolapse, tail bone pain, et al. Pain is a kind of nociceptive feeling. The occurrence of CPP is pain nerve conduction process, mechanical stress and inflammation stimulation are the two main reasons of CPP, in the process of the nerve conduction of pain, neuropeptides are also involved in the regulation of chronic pain.
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慢性盆腔疼痛的致痛机制研究 The Mechanism Research of Chronic Pelvic Pain The Mechanism Research of Chronic Pelvic Pain DOI: 10.12677/ACM.2017.72021, PDF, 被引量 国家自然科学基金支持 作者: 沈宇凤：上海中医药大学附属龙华临床医学院，上海；付金荣：上海中医药大学附属龙华医院妇科，上海 关键词: 慢性盆腔痛；致痛机制；机械压力；炎症因子；神经肽类；Chronic Pelvic Pain； Mechanism of Pain； Mechanical Pressure； Inflammatory Cytokines； Neuropeptides 作者: 沈宇凤：上海中医药大学附属龙华临床医学院，上海；付金荣：上海中医药大学附属龙华医院妇科，上海 关键词: 慢性盆腔痛；致痛机制；机械压力；炎症因子；神经肽类；Chronic Pelvic Pain； Mechanism of Pain； Mechanical Pressure； Inflammatory Cytokines； Neuropeptides 摘要: 慢性盆腔疼痛是妇科的常见病、多发病，病因复杂，诊断困难，常见疾病有子宫内膜异位症、盆腔炎性疾病、盆腔脏器脱垂、尾骨痛等。疼痛是一种伤害性感受，慢性盆腔疼痛的发生是疼痛神经传导的过程，机械压力和炎症的刺激是慢性盆腔疼痛产生的主要原因，在疼痛的神经传导过程中，神经肽类物质也参与慢性疼痛的调控。 Abstract: Chronic pelvic pain (CPP) is a common and frequent gynaecological disease, whose etiology is complex, difficult to diagnosed and involves diseases of multiple systems, common diseases such as endometriosis, pelvic inflammatory disease, interstitial cystitis, irritable bowel syndrome and pelvic organ prolapse, tail bone pain, et al. 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