Expression of ghrelin and its receptors in ovarian endometrioma

Łukasz Milewski, Lukasz Milewski, Katarzyna Wójtowicz, Piotr I Roszkowski, Ewa Barcz, Bogna Ziarkiewicz‐Wróblewska, Bogna Ziarkiewicz-Wróblewska, Paweł Kamiński, Jacek Malejczyk
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2011 · vol. 28(4) , pp. 310–313 · doi:10.3109/09513590.2011.631628 · PMID:22087538 · W2099054857
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This study investigated ghrelin and its receptor expression in endometriotic lesions, finding mRNA and protein presence in epithelial, stromal, and infiltrating leukocyte cells.

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Abstract

Endometriosis is a common gynaecological disorder manifesting by implantation and growth of endometrial tissue outside the uterine cavity. The evidence accumulates that endometriosis may be associated with abrogated regulation of energy balance. Ghrelin is one of the most important orexigenic factor which may also play a role in regulation of inflammatory and angiogenic reactions. The present study was aimed at investigating expression profile of ghrelin and its receptors (GHSR1α and GHSR1β) in endometriotic lesions. The study included ovarian cysts and peritoneal fluid specimens obtained laparoscopically from 20 women with revised American Fertility Society stage III or IV endometriosis. Expression of specific mRNAs was assessed by reverse transcription-polymerase chain reaction. Expression of ghrelin and GHSR1α protein was studied by immunohistochemical staining with specific antibodies. Ghrelin and its receptors mRNA expression was found in all tested specimens. Specific mRNAs for these factors were also expressed in the peritoneal leukocytes. Immunohistochemical staining revealed expression of ghrelin and GHSR1α both in glandular endometrioid epithelium and in some stromal cells, particularly in some fibroblasts, blood vessels and infiltrating leukocytes. Co-localization of ghrelin and its receptors strongly suggests that this neuropeptide may affect development and growth of endometriotic lesions and may influence local inflammatory and angiogenic response.

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Condition tags

mesh:D004715endometriosisendometrioma

MeSH descriptors

Endometriosis Ghrelin Ovarian Cysts Ovarian Diseases Receptors, Ghrelin Endometriosis Endometriosis Endometrium Endometrium Female Ghrelin Ghrelin Humans Ovarian Cysts Ovarian Cysts Ovarian Diseases Ovarian Diseases Peritoneum Peritoneum Receptors, Ghrelin

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References (34)

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