Immunohistochemistrical and Clinicopathological Characterization of Chronic Endometritis

Kotaro Kitaya, Tadahiro Yasuo
In: American Journal of Reproductive Immunology · 2011 · vol. 66(5) , pp. 410–415 · doi:10.1111/j.1600-0897.2011.01051.x · PMID:21749546 · W1558767898
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Chronic endometritis was identified in 11.1% of hysterectomy specimens, with symptomatic cases showing more prominent stromal plasmacyte infiltration and morphological delay compared to asymptomatic ones.

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Abstract

PROBLEM: Chronic endometritis is an elusive entity that is often asymptomatic and undetectable by conventional endometrial biopsy and histological examination. Using immunohistochemistry for full-thickness endometrium, we sought for its clinicopathological features. METHOD OF STUDY: Two hundred and thirty-four archival endometrial specimens obtained by hysterectomy were immunostained for the plasmacyte marker syndecan-1 to identify chronic endometritis. Endometrial morphology was dated by the standard criteria. The immunoreactive cells were enumerated in 10 non-overlapping endometrial stromal areas. The clinical parameters were obtained from the medical charts. RESULTS: Chronic endometritis was identified in 11.1% of the samples examined. Its occurrence was similar between the proliferative phase and secretory phase. A total of 23.1% of the cases were asymptomatic. Stromal plasmacyte infiltration and morphological delay were more prominent in symptomatic chronic endometritis than in asymptomatic counterpart. CONCLUSIONS: Chronic endometritis is a common gynecological pathological condition and more often asymptomatic than ever expected. There was no menstrual cycle-dependent fluctuation in its occurrence.

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