Endometriosis doubles odds for miscarriage in patients undergoing IVF or ICSI

Corinna Pallacks, Pallacks C, Jens Hirchenhain, Hirchenhain J, Jan-Steffen Krüssel, Krüssel JS, Tanja Fehm, Tanja N Fehm, Fehr D, Daniel Fehr
European journal of obstetrics, gynecology, and reproductive biology · 2017 · vol. 213 , pp. 33–38 · doi:10.1016/j.ejogrb.2017.04.008 · PMID:28419910 · W2604390640
Observational OA: closed CC0 ⤵ 17 in-corpus citations
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Endometriosis in women undergoing IVF or ICSI treatment for infertility was associated with a twofold increased risk of miscarriage.

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Abstract

OBJECTIVE: To identify and estimate the importance of risk factors on pregnancy loss until the end of the second trimester after clinical pregnancy was achieved by either in vitro fertilisation (IVF) or intra-cytoplasmic sperm injection (ICSI). STUDY DESIGN: Retrospective cohort study including 588 cycles with fresh embryo transfers and 150 cycles with frozen-thawed embryo transfers using logistic regression. RESULTS: The rate of miscarriages subsequent to a fresh embryo transfer was significantly increased by a diagnosis of endometriosis (p=0.02), as well as significantly influenced by the age of the female patient at the time of oocyte retrieval (p<0.01) and the serum level of testosterone (p=0.02). The time between freezing and thawing of the pronuclear stages for a frozen-thawed embryo transfer revealed a trend to a higher rate of miscarriages (p=0.06). CONCLUSION: Endometriosis significantly decreases the chance of having a baby even with IVF or ICSI.

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Condition tags

endometriosis

MeSH descriptors

Abortion, Spontaneous Endometriosis Fertilization in Vitro Fertilization in Vitro Sperm Injections, Intracytoplasmic Sperm Injections, Intracytoplasmic Abortion, Spontaneous Abortion, Spontaneous Adult Adult Age Factors Age Factors Cohort Studies Cohort Studies Cryopreservation Cryopreservation Embryo Transfer Embryo Transfer Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (40)

Cited by (17)

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