Evidence for oxidatively modified lipid-protein complexes in endometrium and endometriosis
Non-randomised trial
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⤵ 60 in-corpus citations
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Researchers identified oxidatively modified lipid-protein complexes in human endometrium and endometriosis tissue samples.
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Abstract
OBJECTIVE: To evaluate for the presence of oxidatively modified lipid-protein complexes in endometriosis and endometrium of women with endometriosis and controls.
DESIGN: Controlled clinical study.
SETTING: Academic tertiary care center.
PATIENT(S): Women undergoing surgery for pelvic pain, infertility, endometriosis, or tubal ligation controls.
INTERVENTION(S): Biopsy of endometrium and endometriosis.
MAIN OUTCOME MEASURE(S): Staining with antibodies to oxidatively modified lipid proteins (HNE-7, MDA2), macrophages (HAM-56), and muscle cell actin (HHF-35).
RESULT(S): Both endometrium and endometriosis tissues contain stromal cells that immunostain with HAM-56 and show immunostaining (both intracellular and extracellular) with HNE-7 and MDA2. Some endometriotic implants show patchy staining with HHF-35. Endometrium was devoid of staining with HHF-35. Control staining with nonimmune sera in both tissues was also devoid of staining.
CONCLUSION(S): These data strongly implicate the occurrence of oxidative stress in endometriosis tissue. These data also suggest that oxidative modification is a normal physiological process in endometrium.
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- Role of oxidative stress in endometriosis 2006
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