Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model

M S Bostanci, Mehmet Sühha Bostancı, Murat Bakacak, M Bakacak, Bakacak M, Kizilkale Yildirim O, O Kizilkale Yildirim, Oğuzhan Yıldırım, Yildirim G, G Yildirim, G. Yıldırım, R Attar, Rükset Attar, Attar R, Ferda Özkan, F Özkan, Özkan F, Fatma İnanç Tolun, F Inanc Tolun, Inanc Tolun F
Clinical and experimental obstetrics & gynecology · 2016 · vol. 43(4) , pp. 529–533 · doi:10.12891/ceog2114.2016 · PMID:29734542 · W2990590765
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Aloe vera gel inhibited the formation of surgically-induced endometriotic lesions and reduced existing lesions in a rat model, while also increasing antioxidant levels and reducing oxidative stress markers in peritoneal fluid.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

The paper evaluated whether aloe vera gel could prevent the formation of surgically induced endometriosis-like lesions in rats and promote regression of established endometrial explants, using 24 reproductive-aged, non-pregnant female Sprague-Dawley rats. Rats were randomized to control, aloe vera during endometriosis induction, or aloe vera as a treatment after lesion establishment, with peritoneal lavage collected at operations to measure oxidative stress markers (SOD, MDA, CAT) and lesion volumes and histopathological scores assessed across two operations. Aloe vera treatment was associated with lower total lesion volumes (e.g., Group 3 volume decreased after application) and higher antioxidant status with reduced oxidative stress markers, and the authors reported corresponding improvements in histopathological scores. A key limitation is that the study used a rat model with a small sample size and did not include detailed mechanistic controls beyond oxidative stress measurements. This paper is centrally about endometriosis — it tests aloe vera gel’s effects on induction and regression of endometriotic lesions in a rat model.

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Abstract

PURPOSE OF INVESTIGATION: To evaluate the preventive and reducing effect of aloe vera gel on surgically-induced endometrial foci in rats. MATERIALS AND METHODS: Twenty-four reproductive aged female non-pregnant, nulligravid Sprague-Dawley albino rats were used. The rats were randomly divided to three groups (Group 1: control, Group 2: aloe vera endometriosis formation, and Group 3: aloe vera endometriosis treatment). A peritoneal lavage using one-ml saline was taken at all the operations for determination of superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT). Forty-eight horns were implanted in 24 rats. RESULTS: All the implants were properly formed after implantation. In Group 3, before aloe vera application, the sum of the volumes was 87.2 ± 20.4 mm³ and after treatment the volumes dropped to 28.9 ± 14.9 mm3 (p = 0.01). As evaluation of aloe vera on the formation of endometriosis in the second operation in Group 2, the sum of the volumes was 2.9±1.4 mm³ and in Group 1, 118.9 ± 20.0 mm3 (p = 0.001). Likewise, similar changes were observed in the histopatological scores. CONCLUSION: The application of aloe vera was seen to raise antioxidant levels in the peritoneal fluid and to reduce oxidative stress markers. Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions.
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Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model M. S. Bostanci 1,*, M. Bakacak 2, Ö. Kizilkale Yildirim 3, G. Yildirim 3, R. Attar 3, F. Özkan Özkan 4, F. İnanc Tolun 5 1 Department of Obstetrics and Gynecology, Sakarya University Faculty of Medicine Research and Educational Hospital, Sakarya 2 Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaraş 3 Department of Obstetrics and Gynecology, Yeditepe University, Faculty of Medicine, Istanbul 4 Department of Pathology, Yeditepe University, Faculty of Medicine, Istanbul 5 Department of Biochemistry, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaraş (Turkey) Published: 10 Aug 2016 The Author(s). Published by IMR Press. This is an open access article under the CC BY 4.0 license. Abstract Purpose of investigation: To evaluate the preventive and reducing effect of aloe vera gel on surgically-induced endometrial foci in rats. Materials and Methods: Twenty-four reproductive aged female non-pregnant, nulligravid Sprague-Dawley albino rats were used. The rats were randomly divided to three groups (Group 1: control, Group 2: aloe vera endometriosis formation, and Group 3: aloe vera endometriosis treatment). A peritoneal lavage using one-ml saline was taken at all the operations for determination of superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT). Forty-eight horns were implanted in 24 rats. Results: All the implants were properly formed after implantation. In Group 3, before aloe vera application, the sum of the volumes was 87.2 ± 20.4 mm3 and after treatment the volumes dropped to 28.9 ± 14.9 mm3 (p = 0.01). As evaluation of aloe vera on the formation of endometriosis in the second operation in Group 2, the sum of the volumes was 2.9±1.4 mm3 and in Group 1, 118.9 ± 20.0 mm3(p = 0.001). Likewise, similar changes were observed in the histopatological scores. Conclusion: The application of aloe vera was seen to raise antioxidant levels in the peritoneal fluid and to reduce oxidative stress markers. Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Phytotherapy Plant Preparations Animals Antioxidants Antioxidants Catalase Catalase Disease Models, Animal Endometriosis Endometriosis Female Humans Malondialdehyde Malondialdehyde Oxidative Stress Plant Preparations Rats Rats, Sprague-Dawley Superoxide Dismutase

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