S Parthasarathy
ORCID: 0000-0002-3808-6722
· 20 papers in corpus
article
2023
Endometriosis is defined as the presence of endometrial glands or stroma outside the uterus, commonly diagnosed in women of childbearing age frequently with subfertility. Endometriosis is associated with the presence of uterine fibroids, wh…
article
2021
Endometriosis is an inflammatory condition characterised by existence of endometrial tissue in extra uterine locations, being aggressive and invasive can cause a significant decrease in quality of life. Various scientific evidence suggests …
article
2005
article
2005
article
2005
article
2004
article
2002
article
2001
Endometriosis is characterized by the presence of endometrial glands and stroma within the peritoneum and other extrauterine sites. The presence of aromatase, a key enzyme in the biosynthesis of estradiol, has been demonstrated in eutopic e…
article
2000
ObjectiveTo determine the direct action of RU486 on endometrial cell proliferation and to differentiate whether the antioxidant or the antiprogesterone property of RU486 is predominately responsible for its effect on cell growth.DesignIn vi…
other
1999
OBJECTIVE: To measure autoantibodies that recognize oxidatively modified proteins in the sera of women with surgically proven endometriosis. DESIGN: Prospective study. SETTING: Tertiary care academic medical center. PATIENT(S): Women und…
article
1998
review
1998
Our central hypothesis proposes that oxidatively damaged red blood cells (RBCs), apoptotic endometrial cells or undigested endometrial tissue may signal the recruitment and activation of mononuclear phagocytes. Women with endometriosis are …
article
1998
ObjectiveTo evaluate for the presence of oxidatively modified lipid-protein complexes in endometriosis and endometrium of women with endometriosis and controls.DesignControlled clinical study.SettingAcademic tertiary care center.Patient(s)W…
article
1998
Inflammatory processes have been hypothesized to mediate some of the clinical sequelae associated with endometriosis. The peritoneal fluid (PF) of women with endometriosis is known to contain more inflammatory cells and their associated cyt…
article
1998
ObjectiveTo determine whether cultured human peritoneal macrophages have functional scavenger receptor(s) and whether activation of macrophages in endometriosis may involve an increase in scavenger receptor activity.DesignA controlled clini…
review
1998
The word antioxidant has become a household term, and every day we are bombarded with claims of antioxidant protection against a host of diseases. Atherosclerosis, cancer, gastric ulcers, memory loss, rheumatoid arthritis, endometriosis, pr…
other
1998
OBJECTIVE: Our purpose was to examine RU 486 and related compounds on monocyte to macrophage differentiation through scavenger receptors and cellular adhesion. STUDY DESIGN: Human monocytes were isolated, cultured, and treated with dexamet…
article
1997
Peritoneal macrophages are easily isolated by lavage, suggesting that they are either nonadherent or weakly adherent in situ. Cultured macrophages express class A scavenger receptors (SCR), which mediate Ca2+-independent adhesion in vitro. …
article
1996
ObjectiveOur purpose was to examine RU 486 and related compounds on macrophage scavenger receptors and cellular adhesion.Study designTHP-1 cells were activated with phorbol myristate acetate and treated with dexamethasone, levonorgestrel, a…
article
1995
PROBLEM: Macrophages are implicated in the pathophysiology of endometriosis and are influenced by anti-inflammatory steroids as well as anti-oxidants. METHODS: We tested the effect of RU-486, an antiprogesterone, antiglucocorticoid and an a…