Asociación entre endometriosis pélvica y estrés oxidativo

Asociación entre endometriosis pélvica y estrés oxidativo DOI: https://doi.org/10.18597/rcog.121Palabras clave: endometriosis, estrés oxidativo, infertilidad, especies reactivas de oxígenoResumen Objetivo: precisar el estado actual del conocimiento referente a la asociación entre endometriosis pélvica y estrés oxidativo. Materiales y métodos: se realizó búsqueda temática en las bases de datos Sciencedirect y Medline vía Pubmed. Se seleccionaron estudios publicados en lengua inglesa entre enero de 1990 y junio del 2012, que hubieran evaluado la asociación entre estrés oxidativo y endometriosis pélvica. Resultados: de 984 resúmenes identificados, 201 fueron escogidos por tener información relacionada; 110 artículos completos fueron evaluados, 45 que tenían información relevante acorde con el objetivo de la revisión fueron tenidos en cuenta. Existen estudios en humanos y en modelos experimentales que proponen que el estrés oxidativo puede estar involucrado en la fisiopatología de la endometriosis pélvica. Distintos estudios señalan que las mujeres con infertilidad asociada a endometriosis presentan niveles más altos de prooxidantes y más bajos de antioxidantes, con respecto al control sano, en mediciones en líquido peritoneal o tejido endometrial, sin consistencia con los hallazgos en plasma o suero. Conclusiones: no es claro el papel que desempeñan las especies reactivas de oxígeno en la endometriosis pélvica. Este campo se presenta como un atractivo ámbito de investigación en ciencias básicas y aplicadas. Biografía del autor/a Johana Márquez-Lázaro Maricela Viola-Rhenals Álvaro Monterrosa-Castro Referencias bibliográficas Giudice L. Endometriosis. NEJM. 2010;362:2389-98. Vinatier D, Orazi G, Cosson M, Dufour P. Theories of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2001;96:21-34. 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