L’endométriose est-elle une lésion pré-cancéreuse ? Perspectives et implications cliniques

Chene G, G. Chêne, G Chene, J. Caloone, Caloone J, Stéphanie Moret, Moret S, S Moret, K. Le Bail-Carval, Le Bail-Carval K, Chabert P, P. Chabert, Beaufils E, E Beaufils, É. Beaufils, Mellier G, G Mellier, Georges Mellier, Lamblin G, G. Lamblin
Gynecologie, obstetrique & fertilite · 2016 · vol. 44(2) , pp. 106–112 · doi:10.1016/j.gyobfe.2016.01.001 · PMID:26850282 · W2417020354
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the hypothesis that endometriosis may act as a pre-cancerous lesion and discusses the clinical implications of this perspective.

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Abstract

Epidemiological studies have shown a relationship between endometriosis and clear cell/endometrioid ovarian cancers (named "Endometriosis Associated Ovarian Cancer" or EAOC). The recent discovery of signaling pathways (especially the SWI/SNF and PI3K/AKT/mTOR pathways) that linked endometriosis and EAOC could lead to the development of specific biomarkers as ARID1A to screen benign to premalignant endometriosis and to new targeted treatment. Moreover, the better understanding of the pathogenesis of the epithelial ovarian cancer arising from the Fallopian tube could allow new early prevention strategies that will be described in this review.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Precancerous Conditions Adenocarcinoma, Clear Cell Biomarkers Carcinoma, Endometrioid DNA-Binding Proteins Female Genetic Predisposition to Disease Humans Neoplasm Staging Nuclear Proteins Signal Transduction Transcription Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (71)

Cited by (9)

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europepmc
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License: CC0 · commercial use OK