[Is endometriosis a precancerous lesion? Perspectives and clinical implications]

Chene G, G. Chêne, G Chene, J. Caloone, Caloone J, Stéphanie Moret, Moret S, S Moret, K. Le Bail-Carval, Le Bail-Carval K, Chabert P, P. Chabert, Beaufils E, E Beaufils, É. Beaufils, Mellier G, G Mellier, Georges Mellier, Lamblin G, G. Lamblin
Gynecologie, obstetrique & fertilite · 2016 · vol. 44(2) , pp. 106–112 · doi:10.1016/j.gyobfe.2016.01.001 · PMID:26850282 · W2417020354
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper explores the hypothesis that endometriosis may act as a pre-cancerous lesion and discusses the clinical implications of this perspective.

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Abstract

Epidemiological studies have shown a relationship between endometriosis and clear cell/endometrioid ovarian cancers (named "Endometriosis Associated Ovarian Cancer" or EAOC). The recent discovery of signaling pathways (especially the SWI/SNF and PI3K/AKT/mTOR pathways) that linked endometriosis and EAOC could lead to the development of specific biomarkers as ARID1A to screen benign to premalignant endometriosis and to new targeted treatment. Moreover, the better understanding of the pathogenesis of the epithelial ovarian cancer arising from the Fallopian tube could allow new early prevention strategies that will be described in this review.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Precancerous Conditions Precancerous Conditions Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Biomarkers Biomarkers Carcinoma, Endometrioid Carcinoma, Endometrioid DNA-Binding Proteins DNA-Binding Proteins Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (71)

Cited by (8)

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License: CC0 · commercial use OK