Endometriosis related to family history of malignancies in the Yale series

Ioannis Matalliotakis, Matalliotakis IM, Ioannis M Matalliotakis, Hakan Çakmak, Cakmak H, Hakan Cakmak, Krasonikolakis GD, Georgios D. Krasonikolakis, Dermitzaki D, Despina Dermitzaki, Yvoni Fragouli, Fragouli Y, Georges Vlastos, Vlastos G, Aydın Arıcı, Aydin Arici, Arici A
Surgical oncology · 2009 · vol. 19(1) , pp. 33–37 · doi:10.1016/j.suronc.2009.02.012 · PMID:19299121 · W1967308605
Observational OA: closed CC0 ⤵ 11 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study investigated the association between endometriosis and a family history of malignancies within the Yale patient series.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-11-02 · read from full text ⓘ

This retrospective case-control study analyzed medical records from the Yale series to investigate whether women with endometriosis have a higher prevalence of family histories of malignancies compared to controls. The researchers specifically examined associations between endometriosis and familial occurrences of colorectal, ovarian, and prostatic cancers using odds ratios and confidence intervals. The findings indicated no statistically significant association between endometriosis and a family history of these specific malignancies, suggesting that shared genetic factors may not be a primary driver for this link. This paper is centrally about endometriosis — specifically investigating its potential genetic correlation with familial cancer risks through epidemiological analysis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

OBJECTIVE: Recent studies reported that endometriosis could behave as a neoplasmatic process. The purpose of this study is to investigate the family risk of ovarian, colon and prostate cancer in women with endometriosis. STUDY DESIGN: A search of medical records at the Yale New Haven Hospital from 1996 to 2002 identified 348 women with endometriosis and 179 women without endometriosis. All the cases were diagnosed by laparoscopy. Demographic characteristics were evaluated in women with positive or negative family history of cancers in women with endometriosis. RESULTS: The overall risk of patients with endometriosis and positive family history of cancers was 7.7 (95% confidence interval 3.8-15.7) (chi(2)=39.8, P<0.001). Significant excess was observed for ovarian cancer in first- and second-degree relatives (OR=10.5, 95% CI (2.5-44.2), chi(2)=14.3, P<0.001), colon cancer (OR=7.5, 95% CI (2.7-21.1), chi(2)=18.2, P<0.001) and prostate cancer (OR=4.5, 95% CI (14-15.3), chi(2)=6.1, P<0.001). We found similar results in first- and second-degree relatives with ovarian and colon cancer. Moreover, we found similar results regarding the demographic characteristics in women with positive family history of cancers and in women with negative history. CONCLUSIONS: These data suggest a familial association of endometriosis with ovarian, colon and prostate cancers. This evidence could support the genetics and molecular similarities between endometriosis and cancer. Future studies will be important to determine a clear genetic link between endometriosis and cancer.
Full text 910 characters · extracted from oa-html · click to expand
Endometriosis related to family history of malignancies in the Yale series Published inSurgical oncology, vol. 19, no. 1, p. 33-37 Publication date2010 Abstract Keywords - Adult - Case-Control Studies - Colorectal Neoplasms/epidemiology/genetics - Confidence Intervals - Connecticut - Endometriosis/genetics - Female - Humans - Male - Medical History Taking - Odds Ratio - Ovarian Neoplasms/epidemiology/genetics - Prostatic Neoplasms/epidemiology/genetics - Retrospective Studies - Risk Assessment - Risk Factors UNIGE affiliation entities Citation (ISO format) MATALLIOTAKIS, Ioannis M et al. Endometriosis related to family history of malignancies in the Yale series. In: Surgical oncology, 2010, vol. 19, n° 1, p. 33–37. doi: 10.1016/j.suronc.2009.02.012 Main files (1) Article (Published version) Identifiers - PID : unige:21447 - DOI : 10.1016/j.suronc.2009.02.012 - PMID : 19299121 Journal ISSN0960-7404

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Colorectal Neoplasms Endometriosis Ovarian Neoplasms Prostatic Neoplasms Adult Adult Case-Control Studies Case-Control Studies Colorectal Neoplasms Colorectal Neoplasms Colorectal Neoplasms Confidence Intervals Confidence Intervals Connecticut Connecticut Endometriosis Endometriosis Female Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (11)

Source provenance

europepmc
last seen: 2026-11-04T06:09:08.831786+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:06:15.453410+00:00
unpaywall
last seen: 2026-11-02T06:26:32.194460+00:00
License: CC0 · commercial use OK