Endometriosis related to family history of malignancies in the Yale series

Ioannis Matalliotakis, Matalliotakis IM, Ioannis M Matalliotakis, Hakan Çakmak, Cakmak H, Hakan Cakmak, Krasonikolakis GD, Georgios D. Krasonikolakis, Dermitzaki D, Despina Dermitzaki, Yvoni Fragouli, Fragouli Y, Georges Vlastos, Vlastos G, Aydın Arıcı, Aydin Arici, Arici A
Surgical oncology · 2009 · vol. 19(1) , pp. 33–37 · doi:10.1016/j.suronc.2009.02.012 · PMID:19299121 · W1967308605
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This study investigated the association between endometriosis and a family history of malignancies within the Yale patient series.

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Abstract

ObjectiveRecent studies reported that endometriosis could behave as a neoplasmatic process. The purpose of this study is to investigate the family risk of ovarian, colon and prostate cancer in women with endometriosis.Study designA search of medical records at the Yale New Haven Hospital from 1996 to 2002 identified 348 women with endometriosis and 179 women without endometriosis. All the cases were diagnosed by laparoscopy. Demographic characteristics were evaluated in women with positive or negative family history of cancers in women with endometriosis.ResultsThe overall risk of patients with endometriosis and positive family history of cancers was 7.7 (95% confidence interval 3.8-15.7) (chi(2)=39.8, P<0.001). Significant excess was observed for ovarian cancer in first- and second-degree relatives (OR=10.5, 95% CI (2.5-44.2), chi(2)=14.3, P<0.001), colon cancer (OR=7.5, 95% CI (2.7-21.1), chi(2)=18.2, P<0.001) and prostate cancer (OR=4.5, 95% CI (14-15.3), chi(2)=6.1, P<0.001). We found similar results in first- and second-degree relatives with ovarian and colon cancer. Moreover, we found similar results regarding the demographic characteristics in women with positive family history of cancers and in women with negative history.ConclusionsThese data suggest a familial association of endometriosis with ovarian, colon and prostate cancers. This evidence could support the genetics and molecular similarities between endometriosis and cancer. Future studies will be important to determine a clear genetic link between endometriosis and cancer.

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Condition tags

endometriosis

MeSH descriptors

Colorectal Neoplasms Endometriosis Ovarian Neoplasms Prostatic Neoplasms Adult Case-Control Studies Colorectal Neoplasms Colorectal Neoplasms Confidence Intervals Connecticut Endometriosis Female Humans Male Medical History Taking Odds Ratio Ovarian Neoplasms Ovarian Neoplasms Prostatic Neoplasms Prostatic Neoplasms

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