Long‐term survival of a patient with malignant transformation of extragonadal endometriosis treated solely with chemotherapy: A case report

Eiji Kondo, Shintaro Maki, Masafumi Nii, Kenta Yoshida, Tsutomu Tabata, Tomoaki Ikeda
Journal of Obstetrics and Gynaecology Research · 2018 · vol. 44(12) , pp. 2186–2189 · doi:10.1111/jog.13773 · PMID:30133069 · W2888685026
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A 52-year-old woman with extragonadal endometriosis underwent chemotherapy, achieving clinical complete remission for 11 years before recurrence, which was treated with surgery.

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Abstract

Abstract A 52‐year‐old woman presented to our hospital complaining of genital bleeding and was found to have a 50‐mm vaginal tumor that involved the bladder, rectum, and small bowel and extended to the left pelvic side wall. Her history included a bilateral salpingo‐oophorectomy and a total abdominal hysterectomy for fibroids and endometriosis. She had been prescribed estrogen replacement therapy (1.25 mg/day) following the second surgery and continued it for 8 years. The pathology of the vaginal biopsy showed endometrioid adenocarcinoma. Total pelvic exenteration was recommended for complete resection, but she chose chemotherapy (paclitaxel 175 mg/m 2 and carboplatin AUC:6). Clinical complete remission was obtained for 11 years. She had a recurrence 11 years later. She was again found to have a 5‐cm vaginal tumor. Surgical excision with upper vaginectomy was performed. The tumor was resected without invasion of the bladder, rectum and small bowel. Histologic examination of the specimen confirmed clear cell carcinoma with endometriosis. Chemotherapy may be the first‐line treatment that can preclude aggressive surgery for malignant transformation of extragonadal endometriosis. However, combined chemotherapy and surgery is necessary for this disease.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Antineoplastic Agents Carcinoma, Endometrioid Endometriosis Intestinal Neoplasms Neoplasm Recurrence, Local Urinary Bladder Neoplasms Vaginal Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Antineoplastic Agents Carcinoma, Endometrioid Carcinoma, Endometrioid Endometriosis Endometriosis Female Humans Intestinal Neoplasms Intestinal Neoplasms Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (7)

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