Malignant transformation of residual endometriosis after hysterectomy: a case series

V. Karanjgaokar, Vrunda C Karanjgaokar, Karanjgaokar VC, Damian J Murphy, Murphy DJ, Damian Murphy, Jagbir S. Samra, Samra JS, Mann CH, Christopher H. Mann
Fertility and sterility · 2009 · vol. 92(6) , pp. 2037.e19–2037.e21 · doi:10.1016/j.fertnstert.2009.08.012 · PMID:19800063 · W2004388808
article OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This case series examines residual endometriosis and its subsequent malignant transformation in patients who have undergone hysterectomy, detailing observed pathological findings.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo explore the role of long-standing hormone replacement therapy (HRT) in the malignant transformation of endometriosis.DesignShort case series. Three cases of women with pelvic clearance receiving long-standing HRT studied in detail.SettingTeaching hospital in the United Kingdom (Gynaecological Cancer Centre) (Institutional Review Board approval was not obtained as it was not deemed necessary, this being a case series).Patient(s)Women with a history of pelvic clearance for endometriosis and longstanding HRT.Intervention(s)HRT.Main outcome measure(s)Malignant transformation of endometriosis.Result(s)Long-standing HRT in all three women with pelvic clearance for endometriosis resulted in malignant transformation of residual endometriosis many years after the initial surgery. All cases presented with a new pelvic lesion.Conclusion(s)The diagnosis of malignant transformation needs to be considered in women with a history of endometriosis and with long-term HRT use in whom a new pelvic lesion is detected. The risk of malignant transformation in women with endometriosis after pelvic clearance receiving HRT needs to be explored further. Surveillance with CA-125 and imaging in such cases to predict recurrence or malignant transformation needs to be studied further in a research setting.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Adenosarcoma Cell Transformation, Neoplastic Endometrial Neoplasms Endometriosis Endometriosis Hysterectomy Adenosarcoma Adenosarcoma Adenosarcoma Antineoplastic Agents Antineoplastic Agents Combined Modality Therapy Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Estrogen Replacement Therapy Female Humans Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Cited by (12)

Source provenance

europepmc
last seen: 2026-08-03T06:10:56.557307+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:59.677786+00:00
License: CC0 · commercial use OK