Malignant transformation of residual endometriosis after hysterectomy: a case series

V. Karanjgaokar, Vrunda C Karanjgaokar, Karanjgaokar VC, Damian J Murphy, Murphy DJ, Damian Murphy, Jagbir S. Samra, Samra JS, Mann CH, Christopher H. Mann
Fertility and sterility · 2009 · vol. 92(6) , pp. 2037.e19–2037.e21 · doi:10.1016/j.fertnstert.2009.08.012 · PMID:19800063 · W2004388808
Case report OA: closed CC0 ⤵ 11 in-corpus citations
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This case series examines residual endometriosis and its subsequent malignant transformation in patients who have undergone hysterectomy, detailing observed pathological findings.

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Abstract

OBJECTIVE: To explore the role of long-standing hormone replacement therapy (HRT) in the malignant transformation of endometriosis. DESIGN: Short case series. Three cases of women with pelvic clearance receiving long-standing HRT studied in detail. SETTING: Teaching hospital in the United Kingdom (Gynaecological Cancer Centre) (Institutional Review Board approval was not obtained as it was not deemed necessary, this being a case series). PATIENT(S): Women with a history of pelvic clearance for endometriosis and longstanding HRT. INTERVENTION(S): HRT. MAIN OUTCOME MEASURE(S): Malignant transformation of endometriosis. RESULT(S): Long-standing HRT in all three women with pelvic clearance for endometriosis resulted in malignant transformation of residual endometriosis many years after the initial surgery. All cases presented with a new pelvic lesion. CONCLUSION(S): The diagnosis of malignant transformation needs to be considered in women with a history of endometriosis and with long-term HRT use in whom a new pelvic lesion is detected. The risk of malignant transformation in women with endometriosis after pelvic clearance receiving HRT needs to be explored further. Surveillance with CA-125 and imaging in such cases to predict recurrence or malignant transformation needs to be studied further in a research setting.

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Condition tags

endometriosis

MeSH descriptors

Adenosarcoma Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometrial Neoplasms Endometriosis Endometriosis Hysterectomy Hysterectomy Adenosarcoma Adenosarcoma Adenosarcoma Adenosarcoma Antineoplastic Agents Antineoplastic Agents Antineoplastic Agents Combined Modality Therapy Combined Modality Therapy Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (22)

Cited by (12)

Source provenance

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License: CC0 · commercial use OK