Retroperitoneal Squamous Cell Carcinoma Involving the Pelvic Side Wall Arising from Endometriosis: A Case Report

Giuseppe Cucinella, Giulio Sozzi, Sozzi G, Mariano Catello Di Donna, Di Donna MC, Unti E, Elettra Unti, Andrea Mariani, Mariani A, Vito Chiantera, Vito Chiàntera
Gynecologic and obstetric investigation · 2022 · vol. 87(2) , pp. 159–164 · doi:10.1159/000520983 · PMID:35108708 · W4210539261
article OA: closed CC0 ⤵ 4 in-corpus citations
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This case report describes the first instance of retroperitoneal squamous cell carcinoma of the pelvic side wall arising from endometriosis, successfully treated with a laparoscopic approach.

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Abstract

INTRODUCTION: Squamous cell carcinoma (SCC) arising from endometriosis is very rare. Moreover, endometriosis located on the pelvic side wall is uncommon, while its cancerization is quite unusual. We herein report the first case of retroperitoneal SCC arising from endometriosis. CASE PRESENTATION: A case of a 52-year-old woman with retroperitoneal pararectal right mass is presented. The pelvic magnetic resonance imaging showed a retroperitoneal tumor extended to the right pelvic side wall. The neuropelveological examination completed the preoperative assessment, showing a right-sided sciatica and overactive bladder symptoms. Tumor removal was completely managed by a minimally invasive technique through the laparoscopic laterally extended endopelvic resection procedure and pelvic neurolysis. Final histology revealed a SCC in a context of diffuse endometriosis with a histologic continuity between the SCC and the endometriosis. The patient underwent adjuvant chemotherapy with no recurrence after 6 months. CONCLUSION: To the best of our knowledge, the present case represents the first evidence of retroperitoneal SCC of the pelvic side wall arising from endometriosis completely resected by laparoscopic approach. Although its rare occurrence, the gynecologist oncologist should maintain a high index of suspicion for malignant endometriosis transformation in case of retroperitoneal pelvic mass and history of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Squamous Cell Carcinoma, Squamous Cell Endometriosis Endometriosis Endometriosis Endometriosis Laparoscopy Laparoscopy Peritoneal Diseases Female Humans Middle Aged Pelvis Retroperitoneal Space Retroperitoneal Space

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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