Clear Cell Adenocarcinoma Arising in an Adenomyoma of the Broad Ligament

Diogo Torres, Lynn Parker, Lynn P. Parker, Mana Moghadamfalahi, Mary Ann Sanders, Daniel S Metzinger
International journal of surgical pathology · 2014 · vol. 23(2) , pp. 140–143 · doi:10.1177/1066896914539550 · PMID:24942896 · W2124968480
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper reports the first case of clear cell adenocarcinoma arising from ectopic endometrial tissue within an adenomyoma of the broad ligament, supporting the link between endometriosis and this cancer type.

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Abstract

Extrauterine adenomyomas are extremely rare benign tumors of smooth muscles, endometrial glands, and endometrial stroma. Ectopic endometrial glands can undergo malignant change. The ovary is the most common site of malignant change in endometriosis. Cancer arising in extraovarian endometriosis is a rare event with limited cases in the literature. To the best of our knowledge, we present the first case of a clear cell adenocarcinoma arising from foci of ectopic endometrial tissue in an adenomyoma of the broad ligament. It supports the association between endometriomas and clear cell adenocarcinoma. Therefore, patients with a significant history of endometriosis may benefit from close follow-up or definitive surgery.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenomyoma Broad Ligament Neoplasms, Second Primary Peritoneal Neoplasms Adenocarcinoma, Clear Cell Adenomyoma Broad Ligament Endometriosis Endometriosis Female Humans Middle Aged Neoplasms, Second Primary Peritoneal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (6)

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