Ovarian Clear Cell Carcinoma

Montag AG, Anthony Montag, A G Montag, E L Jenison, Eric L. Jenison, Jenison EL, C. Thomas Griffiths, Griffiths CT, C T Griffiths, W R Welch, Welch WR, William R. Welch, P T Lavin, Lavin PT, Philip T. Lavin, R C Knapp, Robert C. Knapp, Knapp RC
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1989 · vol. 8(2) , pp. 85–96 · doi:10.1097/00004347-198906000-00001 · PMID:2469661 · W2046925061
article OA: closed CC0 ⤵ 11 in-corpus citations
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This study analyzed 44 ovarian clear cell carcinoma cases, finding stage at presentation as the most important prognostic factor and noting frequent distant organ and lymph node involvement upon recurrence.

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This clinicopathologic analysis examined 44 cases of pure ovarian clear cell carcinoma to determine clinical and pathologic characteristics. The study found that while endometriosis was present in the ovary or distant sites for nearly sixty percent of patients, it did not directly influence survival outcomes. Stage at presentation emerged as the most significant prognostic factor, whereas tumor grading and specific cell types showed no predictive value for patient survival. Relevance to endometriosis: This paper is centrally about endometriosis — specifically noting its frequent association with ovarian clear cell carcinoma, as nearly 60% of the cohort had concurrent endometriosis.

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Abstract

The clinical aspects and pathologic findings in 44 cases of pure clear cell carcinoma of the ovary are presented. The patients ranged in age from 28 to 78 years (mean, 50.6 years); 54% were nulliparous. Thirty-three percent of the patients had endometriosis in the involved ovary, and an additional 25% had endometriosis only in sites distant from the tumor. Microscopically, three architectural patterns (papillary, tubulocystic, and solid) and four cell types (clear, hobnail, eosinophilic, and flattened) were seen. A predominant tubulocystic architectural pattern was a good prognostic factor (p less than 0.01); however, no significant difference in survival by cell type was found. Grading of the tumors by conventional architectural and cytologic criteria had no predictive value for survival. Stage at presentation was the most important prognostic factor (p less than 0.001), with a 5-year overall survival of 34% and stage I survival of 55%. The poor stage I survival reflects the 15 patients (34%) in the study with stage Iaii lesions. In the 25 patients who developed recurrence, both distant organ involvement (40%) and lymph node involvement (40%) were frequent. Ovarian clear cell carcinoma has unusual pathologic and clinical features, and it represents a distinct histologic type of ovarian carcinoma.
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Ovarian Clear Cell Carcinoma A Clinicopathologic Analysis of 44 Cases - Anthony G. Montag - Eric L. Jenison - C. Thomas Griffiths - William R. Welch - Philip T. Lavin - Robert C. Knapp Summary: The clinical aspects and pathologic findings in 44 cases of pure clear cell carcinoma of the ovary are presented. The patients ranged in age from 28 to 78 years (mean, 50.6 years); 54% were nulliparous. Thirty-three percent of the patients had endometriosis in the involved ovary, and an additional 25% had endometriosis only in sites distant from the tumor. Microscopically, three architectural patterns (papillary, tubulocystic, and solid) and four cell types (clear, hobnail, eosinophilic, and flattened) were seen. A predominant tubulocystic architectural pattern was a good prognostic factor (p < 0.01); however, no significant difference in survival by cell type was found. Grading of the tumors by conventional architectural and cytologic criteria had no predictive value for survival. Stage at presentation was the most important prognostic factor (p < 0.001), with a 5-year overall survival of 34% and stage I survival of 55%. The poor stage I survival reflects the 15 patients (34%) in the study with stage Iaii lesions. In the 25 patients who developed recurrence, both distant organ involvement (40%) and lymph node involvement (40%) were frequent. Ovarian clear cell carcinoma has unusual pathologic and clinical features, and it represents a distinct histologic type of ovarian carcinoma.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Ovarian Neoplasms Adenocarcinoma Adult Aged Female Humans Middle Aged Neoplasm Metastasis Neoplasm Staging Ovarian Neoplasms Staining and Labeling

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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