Strukturwandlungen der Adenomyosis uteri und der Endometriosis externa unter dem Einflu� zugef�hrter Hormone

Dallenbach-Hellweg G, G Dallenbach-Hellweg, Gisela Dallenbach-Hellweg, C Grumbrecht, Grumbrecht C
Virchows Archiv. A, Pathological anatomy and histology · 1975 · vol. 367(3) , pp. 241–254 · doi:10.1007/bf00430711 · PMID:125952 · W2411728730
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This study correlated endometrial, adenomyosis, and endometriosis responses to hormonal stimulation, finding adenomyosis mimicked the endometrium, ovarian endometriosis overreacted, and other endometriosis foci responded weakly.

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This paper studied how endogenous and exogenous hormonal stimulation affects the functional state of the endometrium, adenomyosis, and various endometriosis sites, aiming to see whether endometrial hormonal sensitivity could reflect hormonal therapy effectiveness. It found that responses differed depending on ectopic tissue location and on the duration and intensity of hormone treatment: adenomyosis responded most similarly to the corpus endometrium, ovarian endometriosis often showed an excessive response especially after gestagens, and other extrauterine endometriosis foci reacted only weakly. The authors state that these differences can be predicted with sufficient certainty, implying prognostic implications for hormonal therapy. This paper is centrally about endometriosis and adenomyosis — specifically, how both conditions and their ectopic tissue responsiveness change under administered hormones relative to the endometrium.

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Abstract

This study was undertaken to determine whether the hormonal sensitivity of the endometrium might be a measure of the effectiveness of hormonal therapy for adenomyosis and endometriosis. Accordingly, the effects of endogenous and exogenous hormones on the endometrium, adenomyosis, and endometriosis were correlated. The results revealed that, depending on where the ectopic endometrial tissue was located and on the type (duration and intensity) of hormonal treatment, the functional response of the endometriosis varied from that of the endometrium. The variations, however, can be predicted. The response of adenomyosis to hormonal stimulation was most like that of the endometrium. Endometriosis of the ovary often revealed an excessive response to stimulation, especially after gestagens. The other types of extrauterine foci of endometriosis, however, reacted only weakly to hormonal therapy. Important prognostic consequence for therapy can be drawn from the results.
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Summary This study was undertaken to determine whether the hormonal sensitivity of the endometrium might be a measure of the effectiveness of hormonal therapy for adenomyosis and endometriosis. Accordingly, the effects of endogenous and exogenous hormones on the endometrium, adenomyosis, and endometriosis were correlated. The results revealed that, depending on where the ectopic endometrial tissue was located and on the type (duration and intensity) of hormonal treatment, the functional response of the endometriosis varied from that of the endometrium. The variations, however, can be predicted. The response of adenomyosis to hormonal stimulation was most like that of the endometrium. Endometriosis of the ovary often revealed an excessive response to stimulation, especially after gestagens. The other types of extrauterine foci of endometriosis, however, reacted only weakly to hormonal therapy. Important prognostic consequence for therapy can be drawn from the results. Zusammenfassung Die Hormontherapie der Adenomyose und Endometriose läßt die Beurteilungsmöglichkeit des Heilungserfolges bzw. der Heilungschancen aus dem Funktionszustand des Corpusendometrium wünschenswert erscheinen. Bei systematischer korrelierender Untersuchung von Endometrium, Adenomyose und/oder Endometriose unter dem Einfluß endogener und exogener hormoneller Stimulation ergaben sich je nach Lokalisation des ektopischen Endometrium und nach Art des hormonellen Stimulus in Zeitpunkt und Ausmaß unterschiedliche Abweichungen vom Funktionszustand des Corpusendometrium. Diese lassen sich jedoch mit genügender Sicherheit jeweils voraussagen. Die hormonelle Stimulierung der Adenomyose war der des Corpusendometrium am ähnlichsten, die Endometriose des Ovars zeigte oft, insbesondere unter Gestagenreizen, eine überschießende Stimulation, während die übrigen extrauterinen Endometriosherde nur sehr schwach auf hormonelle Reize reagierten. Aus den Ergebnissen lassen sich für die Therapie wichtige prognostische Konsequenzen ableiten. Similar content being viewed by others Literatur Dito, W. R., Batsakis, J. G.: Norethynodrel-treated endometriosis: A morphologic and histochemical study. Obstet, and Gynec. 18, 1 (1961) Ferin, J.: Arteficial induction of hypoestrogenic amenorrhoea with methylestrenolon or with lynestrenol. Acta endocr. (Kbh.) 39, 47 (1962) Gray, L. A., Barnes, M. L.: Stilbestrol treatment of endometriosis. Report of a case. Amer. J. Obstet. Gynec. 66, 448 (1953) Haskins, A. L., Woolf, R. B.: Stilbestrol-induced hyperhormonal amenorrhea for the treatment of pelvic endometriosis. Obstet. and Gynec. 5, 113 (1955) Husslein, H.: Die Endometriose. Fortschr. Med. 88, Nr. 2 (1970) Kistner, R. W.: The use of newer progestins in the treatment of endometriosis. Amer. J. Obstet. Gynec. 75, 264 (1958) Kistner, R. W.: Infertility with endometriosis. Fertil. and Steril. 13, 237 (1962) Kistner, R. W.: Current status of the hormonal treatment of endometriosis. Clin. obstetrics and gynec., vol. 9, No. 2. New York: Hoeber Med. Div. 1966 Lauslahti, K.: Malignant external endometriosis. Acta path. microbiol. scand., Sect. A, 80, Suppl. 233, 98 (1972) Reintoft, I., Lange, A. P., Skipper, A.: Coincidence of granulosa-cell tumour of ovary and development of carcinoma in rectal endometriosis. Acta obstet. gynec. scand. 53, 185 (1974) Rechter, K.: Die konservative Behandlung der Endometriose. Geburtsh. u. Frauenheilk. 9, 737 (1964) Schmid, K. O.: Zum wechselnden morphologischen Erscheinungsbild der Endometriose. Arch. Gynäk. 212, 413 (1972) Scott, R. B.: Endometriosis and pregnancy. Amer. J. Obstet. Gynec. 47, 608 (1944) Author information Authors and Affiliations Additional information Mit Unterstützung der Deutschen Forschungsgemeinschaft. Rights and permissions About this article Cite this article Dallenbach-Hellweg, G., Grumbrecht, C. Strukturwandlungen der Adenomyosis uteri und der Endometriosis externa unter dem Einfluß zugeführter Hormone. Virchows Arch. A Path. Anat. and Histol. 367, 241–254 (1975). https://doi.org/10.1007/BF00430711 Received: Issue date: DOI: https://doi.org/10.1007/BF00430711

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Uterine Neoplasms Abdominal Muscles Abdominal Neoplasms Abdominal Neoplasms Abdominal Neoplasms Adult Aged Appendiceal Neoplasms Appendiceal Neoplasms Appendiceal Neoplasms Drug Therapy, Combination Endometriosis Endometriosis Estrogens Estrogens Fallopian Tube Neoplasms Fallopian Tube Neoplasms Fallopian Tube Neoplasms Female

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