Endometriosis: A Malignant Fingerprint

Christopher DeAngelo, Megan Burnett Tarasiewicz, Megan E. Burnett Tarasiewicz, Athena M. Strother, Athena Strother, Heather Taggart, Caron Gray, Meaghan Shanahan, Christopher Glowacki, C Glowacki, Jimmy Khandalavala, Erin Talaska, Andrea Kinnan, John Joseph Coté, John Coté, Adrienne Perfilio Edwards, Gina Harper-Harrison, Murray Joseph Casey, Traci-Lynn Hirai, Sarah Schultz, Lynnea Stines, Roma Vora, Dominique Boudreau, Dominique K. Boudreau, Jennifer Burgart, Meredith Shama, Trevor Watson, Lisa Strasheim, Rachel Thompson, R. Thompson, Rachel Lawlor, Kayleen Joyce, Claire M Magnuson, Jane E. Driano, Jane Driano, Breanna Elger, Anne Lentino, Margaret Driscoll, Margaret E. Driscoll, Elise Tidwell, Apoorva Sharma, Sarah R Walker, Gretchen Jones, Poonam Sharma, Holly Stessman, Holly A.F. Stessman, Yanyuan Wu, Jay Vadgama, Jaydutt V. Vadgama, Dana Chase, Dana M. Chase, Lesley Conrad, Lesley B. Conrad, Srinivasa T Reddy, Robin Farias-Eisner, Robin Farias‐Eisner
Journal of cancer research and therapeutic oncology · 2020 · vol. 8(2) · doi:10.17303/jcrto.2020.8.206 · PMID:33644256 · W3135651192
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Abstract

BACKGROUND: Endometriosis is complex, but identifying the novel biomarkers, inflammatory molecules, and genetic links holds the key to the enhanced detection, prediction and treatment of both endometriosis and endometriosis related malignant neoplasia. Here we review the literature relating to the specific molecular mechanism(s) mediating tumorigenesis arising within endometriosis. METHODS: Guidance (e.g. Cochrane) and published studies were identified. The Published studies were identified through PubMed using the systematic review methods filter, and the authors' topic knowledge. These data were reviewed to identify key and relevant articles to create a comprehensive review article to explore the molecular fingerprint associated with in endometriosis-driven tumorigenesis. RESULTS: An important focus is the link between C3aR1, PGR, ER1, SOX-17 and other relevant gene expression profiles and endometriosis-driven tumorigenesis. Further studies should also focus on the combined use of CA-125 with HE-4, and the role for OVA1/MIA as clinically relevant diagnostic biomarkers in the prediction of endometriosis-driven tumorigenesis. CONCLUSIONS: Elucidating endometriosis' molecular fingerprint is to understand the molecular mechanisms that drive the endometriosis-associated malignant phenotype. A better understanding of the predictive roles of these genes and the value of the biomarker proteins will allow for the derivation of unique molecular treatment algorithms to better serve our patients.

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endometriosis

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