Endometriosis associated with Stage IA clear cell ovarian carcinoma in a woman with IVF-ET treatments in the Yale Series

Matalliotakis I, Ioannis Matalliotakis, Mahutte NG, Neal G Mahutte, Neal Mahutte, Ourania Koukoura, Koukoura O, Aydın Arıcı, Aydin Arici, Arici A
Archives of gynecology and obstetrics · 2006 · vol. 274(3) , pp. 184–186 · doi:10.1007/s00404-006-0143-1 · PMID:16525789 · W2087003566
article OA: closed CC0 ⤵ 15 in-corpus citations
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-08 ⓘ

This case report details a 42-year-old woman with Stage IA clear cell ovarian carcinoma arising in an endometrioma following multiple IVF-ET treatments and cystectomies.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-17 · read from full text ⓘ

This case report describes a 42-year-old woman who developed Stage IA grade 3 clear cell ovarian carcinoma within an endometrioma following multiple cycles of in vitro fertilization and embryo transfer. The patient had undergone two prior laparoscopic cystectomies for left ovarian endometriomas, highlighting the coexistence of these conditions despite previous surgical interventions. The authors note that while some studies suggest fertility treatments may increase cancer risk, others propose a protective effect from successful pregnancies, yet this case demonstrates that parity does not necessarily protect infertile patients from developing ovarian malignancies. This paper is centrally about endometriosis — specifically its association with clear cell ovarian carcinoma arising within an endometrioma.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

A 42-year-old woman with Stage IA, grade 3 clear cell ovarian carcinoma arising within an endometrioma after multiple ovarian stimulation attempts was a unique case from a total of 900 patients who underwent laparoscopy for infertility and pelvic pain between 1996 and 2002 at Yale University. Her previous treatments included two laparoscopic cystectomies for left ovarian endometriomas and four cycles of IVF-ET that resulted in one miscarriage and two successful pregnancies. Although it has been suggested that controlled ovarian hyperstimulation may predispose to the development of ovarian cancer, more recent studies postulate a protective effect if fertility treatments ultimately result in successful pregnancy. Our unusual case serves as a reminder that clear cell adenocarcinoma may coexist with endometriosis, and that parity does not necessarily protect infertility patients against the development of ovarian cancer.
Full text 2,380 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Abstract

A 42-year-old woman with Stage IA, grade 3 clear cell ovarian carcinoma arising within an endometrioma after multiple ovarian stimulation attempts was a unique case from a total of 900 patients who underwent laparoscopy for infertility and pelvic pain between 1996 and 2002 at Yale University. Her previous treatments included two laparoscopic cystectomies for left ovarian endometriomas and four cycles of IVF-ET that resulted in one miscarriage and two successful pregnancies. Although it has been suggested that controlled ovarian hyperstimulation may predispose to the development of ovarian cancer, more recent studies postulate a protective effect if fertility treatments ultimately result in successful pregnancy. Our unusual case serves as a reminder that clear cell adenocarcinoma may coexist with endometriosis, and that parity does not necessarily protect infertility patients against the development of ovarian cancer. Similar content being viewed by others

References

Komiyama S, Aoki D, Tominaga E, Susumu N, Udagawa Y, Nozawa S (1999) Prognosis of Japanese patients with ovarian clear cell carcinoma associated with pelvic endometriosis: clinicopathologic evaluation. Gynecol Oncol 72:342–346 Venn A, Watson L, Bruinsma F, Giles G, Healy D (1999) Risk of cancer after use of fertility drugs with in-vitro fertilization. Lancet 354:1586–1590 Dor J, Lerner-Geva L, Rabinovici J, Chetrit A, Levran D, Lunenfeld B, et al. (2002) Cancer incidence in a cohort of infertile women who underwent in vitro fertilization. Fertil Steril 77:324–327 Kashyap S, Moher D, Funf MF, Rosenwaks Z (2004) Assisted reproductive technology and the incidence of ovarian cancer: a meta-analysis. Obstet Gynecol 103:785–794

Acknowledgements

We are grateful for the assistance of the participating clinicians in the Division of Reproductive Endocrinology and Infertility at Yale University School of Medicine. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Matalliotakis, I., Mahutte, N.G., Koukoura, O. et al. Endometriosis associated with Stage IA clear cell ovarian carcinoma in a woman with IVF-ET treatments in the Yale Series. Arch Gynecol Obstet 274, 184–186 (2006). https://doi.org/10.1007/s00404-006-0143-1 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-006-0143-1

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Endometriosis Ovarian Diseases Ovarian Neoplasms Ovulation Induction Uterine Diseases Adenocarcinoma, Clear Cell Adult Endometriosis Female Fertilization in Vitro Humans Neoplasm Staging Ovarian Diseases Ovarian Neoplasms Ovulation Induction Uterine Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (4)

Cited by (14)

Source provenance

europepmc
last seen: 2026-09-06T09:34:12.023084+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:23.967219+00:00
unpaywall
last seen: 2026-09-06T06:31:40.515551+00:00
License: CC0 · commercial use OK