Endometriosis and Adverse Pregnancy Outcomes, controversies debates

Fatemeh Shahmoradi, Ladan Haghighi, Marziyeh Noori, Roya Derakhshan, Neda Hashemi, Samaneh Rokhgireh
In: Research Square · 2022 · doi:10.21203/rs.3.rs-2290558/v1 · W4309731609
preprint OA: green CC0
📄 Open PDF View on OpenAlex View at publisher

Abstract

Abstract The association between endometriosis and outcome of pregnancy is one of the interesting topics. Patients' pain is alleviated with pregnancy, but it seems that endometriosis causes adverse outcomes in pregnancy. The main accused is systemic chronic inflammation caused by higher level of cytokines, growth factors and angiogenic factors. In this retrospective cohort study, the case group included 125 women with endometriosis who referred to Hazrat-e- Rasool hospital in 2015–2019, and the control group included 125 women without endometriosis who went to the hospital for delivery in 2015–2019. Data on pregnancy, delivery and newborns of the endometriosis and control group was extracted from the hospital information system and the questionnaires were completed. The average age of patients was 32.74 ± 4.10 and 31.7 ± 5.53 years in endometriosis and control group respectively. In terms of pregnancy complications, placenta previa, placenta accreta, placenta abruption pre-eclampsia, GDM and postpartum hemorrhage remarkably increase in the endometriosis group compared to the control group (P < 0.05). In bowel endometriosis SGA was significantly higher than patients without bowel endometriosi. (P 0.05). As well as the presence of adenomyosis made pregnancy outcomes significantly unfavorable compared to people without adenomyosis. (P < 0.05). NICU admission rate was notably higher in infants of endometriosis group compared to controls (40.7% vs. 24.8%, P-value 0.009). Infant mortality rate had no significant difference in both groups (P = 0.12). Our findings showed that endometriosis and adenomyosis are related to bad obstetric consequences.

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosisbowel_endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Source provenance

europepmc
last seen: 2026-06-04T01:45:00.660873+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK